REM Sleep Behavior Disorder
Overview. Rapid eye movement (REM) sleep behavior disorder is a sleep disorder in which you physically act out vivid, often unpleasant dreams with vocal sounds and sudden, often violent arm and leg movements during REM sleep — sometimes called dream-enacting behavior.
Wiki Number: PW185
Diagnosis: Rapid Eye-Movement Sleep Behavior Disorder
US Patients: 5-13% of those aged 60-99;Of those suffering, 33-65% have injured themselves or a bed-partner.
World Patients: Most people with this diagnosis will develop synucleinopathy (proteins clumping up) leading to Parkinson’s/Lewy-Body Dementia.
Sex Ratio: M+;W
Age Onset: 50’s & 60’s
Brain Area: neurodegenerative disorder; pontomedullary brainstem and/or caudal brainstem have lesions and may lead to synucleinopathy
Symptoms: while still sleeping, people act out their dreams; may injure their bed-partner through punching, flailing, running, etc.;
Progression: This condition has also been diagnosed in animals, spefically dogs.
Causes: Parkinson’s, Lewy Body Dementia and similar conditions often do this; muscle weakness or paralysis may be a factor
Medications: melotonin and clonazepam; some other medications may worsen this.
Therapies: placing cushions around the bed or moving the mattress to the floor; keeping a normal sleep schedule, avoding alcohol, etc
Youtube Video: Rem Sleep Behavior Disorder
Amazon or Library Book: Paradox Lost:
Midnight on the Battleground of Sleep and Dreams
Violent Moving Nightmares-REM Sleep Behavior Disorders
Click the book to link or order from Amazon.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Montreal Cognitive Assessment Predicts the Short-Term Risk of Lewy Body Disease in Isolated REM Sleep Behavior Disorder with Reduced MIBG Scintigraphyby Masayuki Miyamoto on January 26, 2023
CONCLUSIONS: Among IRBD patients with reduced cardiac MIBG accumulation, MoCA-J score of <26 (Mild Cognitive Impairment-Lewy body) and a low sub-item score for delayed recall predicted short-term progression to probable DLB.
- α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradationby Jing Kai Fan on January 23, 2023
Rapid eye movement (REM) sleep behavior disorder (RBD) is a powerful early sign of Parkinson's disease (PD), but the pathogenetic mechanism involved in RBD remains largely unexplored. α-Synuclein has been verified to form Lewy bodies in the orexin neurons, whose activity and function rely on the orexin 1 receptor (OX1R). Dysfunction of the OX1R may induce the occurrence of RBD. Here, we determined the role of the interaction between α-Synuclein and OX1R in the pathogenesis of RBD, in vitro and...
- New insights from a multi-ethnic Asian progressive supranuclear palsy cohortby Shen-Yang Lim on January 22, 2023
CONCLUSIONS: Significant heterogeneity in clinical features and disease burden, and high rates of RBD symptoms, visual hallucinations, and familial involvement were observed in this relatively large cohort. Our findings highlight important considerations when assessing Asian patients, and provide further support for the notion of overlapping neurobiology between PSP and Lewy body disorders.
- Sex differences in dementia with Lewy bodies: Focused review of available evidence and future directionsby Shannon Y Chiu on January 22, 2023
In this review, we summarize the current knowledge on sex differences in dementia with Lewy bodies (DLB) relating to epidemiology, clinical features, neuropathology, biomarkers, disease progression, and caregiving. While many studies show a higher DLB prevalence in men, this finding is inconsistent and varies by study approach. Visual hallucinations may be more common and occur earlier in women with DLB, whereas REM sleep behavior disorder may be more common and occur earlier in men. Several...