REM Sleep Behavior Disorder
Overview. Rapid eye movement (REM) sleep behavior disorder is a sleep disorder in which you physically act out vivid, often unpleasant dreams with vocal sounds and sudden, often violent arm and leg movements during REM sleep — sometimes called dream-enacting behavior.
Cluster Number:
Wiki Number: PW185
Diagnosis: Rapid Eye-Movement Sleep Behavior Disorder
US Patients: 5-13% of those aged 60-99;Of those suffering, 33-65% have injured themselves or a bed-partner.
World Patients: Most people with this diagnosis will develop synucleinopathy (proteins clumping up) leading to Parkinson’s/Lewy-Body Dementia.
Sex Ratio: M+;W
Age Onset: 50’s & 60’s
Brain Area: neurodegenerative disorder; pontomedullary brainstem and/or caudal brainstem have lesions and may lead to synucleinopathy
Symptoms: while still sleeping, people act out their dreams; may injure their bed-partner through punching, flailing, running, etc.;
Progression: This condition has also been diagnosed in animals, spefically dogs.
Causes: Parkinson’s, Lewy Body Dementia and similar conditions often do this; muscle weakness or paralysis may be a factor
Medications: melotonin and clonazepam; some other medications may worsen this.
Therapies: placing cushions around the bed or moving the mattress to the floor; keeping a normal sleep schedule, avoding alcohol, etc
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Comprehensive Analysis of Brain Volume in REM Sleep Behavior Disorder with Mild Cognitive Impairmentby David Rémillard-Pelchat on October 25, 2021
CONCLUSION: The present study identified novel brain structural alterations in RBD patients with MCI which correlated with poorer cognitive performance. These results are consistent with those reported in patients with synucleinopathies-related cognitive impairment.
- Rare PSAP Variants and Possible Interaction with GBA in REM Sleep Behavior Disorderby Yuri L Sosero on October 25, 2021
CONCLUSION: These results suggest a possible role of PSAP variants in iRBD and potential genetic interaction with GBA, which requires additional studies.
- The influence of parasomnia on clinical and functional characteristics of extrapyramidal disordersby K S Doronina on October 25, 2021
CONCLUSION: Presence of RBD aggravates non-motor manifestations of such extrapyramidal diseases as PD and ET. On the one hand it helps to predict the course of the disease, on the other hand let us suspect RBD when we see non-motor symptoms worsening.
- Lower calcium levels in hair of Parkinson's disease patients are associated with presence of sleeping disturbancesby Altair Brito Dos Santos on October 25, 2021
Objectives: To investigate the correlation between sleep disorders and the concentrations of three metals analyzed from hair samples of PD patients.The hypothesis of an involvement of an imbalance of metals in the development of Parkinson's Disease (PD) has been strengthened by several clinical chemistry studies. Interestingly, while sparse, some studies have correlated the imbalance of metals in PD patients with comorbidities present in this disease. Although not all PD sufferers present sleep...