REM Sleep Behavior Disorder
Overview. Rapid eye movement (REM) sleep behavior disorder is a sleep disorder in which you physically act out vivid, often unpleasant dreams with vocal sounds and sudden, often violent arm and leg movements during REM sleep — sometimes called dream-enacting behavior.
Cluster Number:
Wiki Number: PW185
Diagnosis: Rapid Eye-Movement Sleep Behavior Disorder
US Patients: 5-13% of those aged 60-99;Of those suffering, 33-65% have injured themselves or a bed-partner.
World Patients: Most people with this diagnosis will develop synucleinopathy (proteins clumping up) leading to Parkinson’s/Lewy-Body Dementia.
Sex Ratio: M+;W
Age Onset: 50’s & 60’s
Brain Area: neurodegenerative disorder; pontomedullary brainstem and/or caudal brainstem have lesions and may lead to synucleinopathy
Symptoms: while still sleeping, people act out their dreams; may injure their bed-partner through punching, flailing, running, etc.;
Progression: This condition has also been diagnosed in animals, spefically dogs.
Causes: Parkinson’s, Lewy Body Dementia and similar conditions often do this; muscle weakness or paralysis may be a factor
Medications: melotonin and clonazepam; some other medications may worsen this.
Therapies: placing cushions around the bed or moving the mattress to the floor; keeping a normal sleep schedule, avoding alcohol, etc
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Prevalence and Correlates of Psychiatric Comorbidity and Multimorbidity in Parkinson's Disease and Atypical Parkinsonian Syndromesby Vinit Patel on May 17, 2022
CONCLUSION: Psychiatric illness is highly comorbid among patients with PD/APS, with most having multiple co-occurring psychiatric illnesses. Clinicians must be aware to ensure early detection and intervention.
- REM sleep behavior disorder as a remote precedent to Creutzfeldt-Jakob diseaseby Sally El Sammak on May 17, 2022
No abstract
- Reduced Intracortical Facilitation to TMS in Both Isolated REM Sleep Behavior Disorder (RBD) and Early Parkinson's Disease with RBDby Giuseppe Lanza on May 14, 2022
CONCLUSIONS: iRBD and PD with RBD shared a reduced ICF, thus suggesting the involvement of glutamatergic transmission both in subjects at risk for degeneration and in those with an overt α-synucleinopathy.
- Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Studyby Yaping Liu on May 13, 2022
CONCLUSIONS: pRBD has a predictive progression in both pathophysiology and neurodegenerative outcome. This finding has significant implications to the nosological status of pRBD, the current REM sleep-related EMG diagnostic criteria, spectrum concept of RBD and future neuroprotective intervention.