REM Sleep Behavior Disorder
Overview. Rapid eye movement (REM) sleep behavior disorder is a sleep disorder in which you physically act out vivid, often unpleasant dreams with vocal sounds and sudden, often violent arm and leg movements during REM sleep — sometimes called dream-enacting behavior.
Cluster Number:
Wiki Number: PW185
Diagnosis: Rapid Eye-Movement Sleep Behavior Disorder
US Patients: 5-13% of those aged 60-99;Of those suffering, 33-65% have injured themselves or a bed-partner.
World Patients: Most people with this diagnosis will develop synucleinopathy (proteins clumping up) leading to Parkinson’s/Lewy-Body Dementia.
Sex Ratio: M+;W
Age Onset: 50’s & 60’s
Brain Area: neurodegenerative disorder; pontomedullary brainstem and/or caudal brainstem have lesions and may lead to synucleinopathy
Symptoms: while still sleeping, people act out their dreams; may injure their bed-partner through punching, flailing, running, etc.;
Progression: This condition has also been diagnosed in animals, spefically dogs.
Causes: Parkinson’s, Lewy Body Dementia and similar conditions often do this; muscle weakness or paralysis may be a factor
Medications: melotonin and clonazepam; some other medications may worsen this.
Therapies: placing cushions around the bed or moving the mattress to the floor; keeping a normal sleep schedule, avoding alcohol, etc
Youtube Video: Rem Sleep Behavior Disorder
Amazon or Library Book: Paradox Lost:
Midnight on the Battleground of Sleep and Dreams
Violent Moving Nightmares-REM Sleep Behavior Disorders
Click the book to link or order from Amazon.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Concordance and test-retest consistency of sleep biomarker-based neurodegenerative disorder profilingby Daniel J Levendowski on December 29, 2024
Biomarkers that aid in early detection of neurodegeneration are needed to enable early symptomatic treatment and enable identification of people who may benefit from neuroprotective interventions. Increasing evidence suggests that sleep biomarkers may be useful, given the bi-directional relationship between sleep and neurodegeneration and the prominence of sleep disturbances and altered sleep architectural characteristics in several neurodegenerative disorders. This study aimed to demonstrate...
- Prediction of Phenoconversion into Alpha-Synucleinopathy in Patients with isolated REM Sleep Behavior Disorder Using Event-Related Potentials During Visuospatial Attention Tasksby Kang-Min Choi on December 28, 2024
CONCLUSION: Our findings suggest that altered cue-elicited ERPs could serve as early biomarkers for predicting phenoconversion in iRBD patients, likely reflecting attention-related neurodegeneration pathways. These biomarkers potentially enable the detection of preclinical phenotypes in alpha-synucleinopathies, facilitating timely intervention.
- Impact of dopamine deficiency and REM sleep behavior disorder on cognition in early neuronal synuclein disease with hyposmiaby Daniel Weintraub on December 23, 2024
OBJECTIVES: To determine the impact of dopamine deficiency and isolated REM sleep behavior disorder (iRBD) on cognitive performance in early neuronal alpha-synuclein disease (NSD) with hyposmia.
- Subthalamic gamma Oscillation Underlying Rapid Eye Movement Sleep Abnormality in Parkinsonian Patientsby Lingxiao Guan on December 21, 2024
CONCLUSION: Excess subthalamic γ oscillations may contribute to REM instability and RBD, suggesting that γ oscillation could serve as a feedback signal for adaptive DBS for REM sleep disorders. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.