REM Sleep Behavior Disorder
Overview. Rapid eye movement (REM) sleep behavior disorder is a sleep disorder in which you physically act out vivid, often unpleasant dreams with vocal sounds and sudden, often violent arm and leg movements during REM sleep — sometimes called dream-enacting behavior.
Cluster Number:
Wiki Number: PW185
Diagnosis: Rapid Eye-Movement Sleep Behavior Disorder
US Patients: 5-13% of those aged 60-99;Of those suffering, 33-65% have injured themselves or a bed-partner.
World Patients: Most people with this diagnosis will develop synucleinopathy (proteins clumping up) leading to Parkinson’s/Lewy-Body Dementia.
Sex Ratio: M+;W
Age Onset: 50’s & 60’s
Brain Area: neurodegenerative disorder; pontomedullary brainstem and/or caudal brainstem have lesions and may lead to synucleinopathy
Symptoms: while still sleeping, people act out their dreams; may injure their bed-partner through punching, flailing, running, etc.;
Progression: This condition has also been diagnosed in animals, spefically dogs.
Causes: Parkinson’s, Lewy Body Dementia and similar conditions often do this; muscle weakness or paralysis may be a factor
Medications: melotonin and clonazepam; some other medications may worsen this.
Therapies: placing cushions around the bed or moving the mattress to the floor; keeping a normal sleep schedule, avoding alcohol, etc
Youtube Video: Rem Sleep Behavior Disorder
Amazon or Library Book: Paradox Lost:
Midnight on the Battleground of Sleep and Dreams
Violent Moving Nightmares-REM Sleep Behavior Disorders
Click the book to link or order from Amazon.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Characterization of Sleep Structure and Autonomic Dysfunction in REM Sleep Behavior Disorderby Nicla Mandas on November 19, 2024
Goal: REM Sleep Behavior Disorder (RBD) is a REM parasomnia that is associated to high risk of developing α-synucleinopathies, as Parkinson's disease (PD) or dementia with Lewy bodies, over time. This study aims at investigating the presence of autonomic dysfunctions in RBD subjects, with and without PD, by assessing their sleep structure and autonomous nervous system activity along the different sleep stages. Methods: To this aim, an innovative framework combining a sleep transition model, by...
- CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorderby Monica Pinoli on November 14, 2024
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4^(+) T cells exhibit a peculiar transcription factor pattern.Objective: To assess transcription factor mRNA levels in CD4^(+) T cells as predictive biomarkers of phenoconversion in iRBD patients.Methods: iRBD patients were followed prospectively. ROC curve analysis and...
- Pharmacological and non-pharmacological management of sleep disturbances in Parkinson's disease: if when and howby Cristian Falup-Pecurariu on November 13, 2024
INTRODUCTION: Sleep dysfunction occurs in various forms and is a bothersome and intrusive non-motor symptom of Parkinson's disease (PD). Frequently undiagnosed, their poor management can have a great impact on the quality of life of PD patients and their caregivers.
- REM sleep behavior disorder: Relation between aggressiveness and emotions expressed in dream enactment and cognitive and anxiety/depression statusby Paulo Bugalho on November 13, 2024
Aggressiveness and negative emotions in dreams reports of patients with alfa-synucleinopathies have been associated with cognitive dysfunction. Observation of dream enactment episodes could be a more precise method to capture dream content in patients with REM sleep behavior disorder (RBD). Our objective was to assess the relation between aggressive and emotional dream enactment episodes in patients with RBD and cognition and depression/anxiety. Motor events (ME) during REM sleep were classified...