Premenstrual dysphoric disorder
Wiki Number: PW175
Diagnosis: Premenstrual Dypshoric Disorder
World Patients: 1.8-5.8% of menstruating women.
Brain Area: serotonin receptors in the hippocampus and prefrontal cortex are affected by estrogen and progesterone activities
Symptoms: pain and mood changes for up to two weeks before menstruation.
Causes: genetic and fluctuating hormones during the menstrual cycle;
Medications: antidepressants, SSRIs, ovulation suppression with birth-control pills and GnRH analogues. SSRIs are most common & help 50%.
4 CURRENT ARTICLES
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- GABRB2, a key player in neuropsychiatric disorders and beyondby Manel Barki on October 21, 2021
The GABA receptors represent the main inhibitory system in the central nervous system that ensure synaptogenesis, neurogenesis, and the regulation of neuronal plasticity and learning. GABA(A) receptors are pentameric in structure and belong to the Cys-loop superfamily. The GABRB2 gene, located on chromosome 5q34, encodes the β(2) subunit that combines with the α and γ subunits to form the major subtype of GABA(A) receptors, which account for 43% of all GABA(A) receptors in the mammalian brain....
- Assessment of premenstrual symptoms: validation of the Italian version of the Premenstrual Symptoms Screening Toolby Francesca Pacitti on October 19, 2021
CONCLUSION: Our results support the cross-cultural validity of the questionnaire, suggesting that the Italian version is a reliable and valid tool, as well as easy to use, to screen women in need of treatment for their premenstrual symptoms.
- Pilot Data on the Feasibility And Clinical Outcomes of a Nomegestrol Acetate Oral Contraceptive Pill in Women With Premenstrual Dysphoric Disorderby Emily Robertson on October 11, 2021
CONCLUSIONS: This preliminary study supports the acceptability and effectiveness of nomegestrol acetate/17-beta estradiol as a treatment for mood symptoms in PMDD. Further research, particularly a randomized controlled trial, is required to elucidate the effect of nomegestrol acetate/17-beta estradiol treatment on mood in PMDD.
- Premenstrual Exacerbations of Mood Disorders: Findings and Knowledge Gapsby Christine Kuehner on October 9, 2021
PURPOSE OF REVIEW: In contrast to premenstrual dysphoric disorder (PMDD), premenstrual exacerbations (PMEs) of ongoing mood disorders are understudied. The aim of this review is to describe diagnostic issues, epidemiology, underlying mechanisms, and treatment for PME in unipolar depression and bipolar disorder, and to discuss clinical and research implications.