Premature ejaculation (PE) is when you have an orgasm before intercourse or less than a minute after you start. There is no set time when a man should ejaculate during sex, but if you ejaculate and lose your erection this soon, you and your partner may feel there’s not enough time to enjoy it.
Wiki Number: PW174
Diagnosis: Premature Ejaculation
US Patients: 4-8 minutes is typical ejaculation.
Symptoms: Male has orgasm and expels semen with minimal penile stimulation.
Medications: SSRIs slowed the process, but had negative side effects later.
Therapies: Stopping movement before ejaculation helped 50% of couples in studies.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
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PubMed article’s summary-abstract.
- Determination of Dapoxetine Hydrochloride in Human Plasma by HPLC-MS/MS and Its Application in a Bioequivalence Studyby Xin Zhang on May 14, 2022
Dapoxetine is used for the treatment of premature ejaculation. The present study developed an HPLC-MS/MS method to determine the levels of dapoxetine in human plasma processed using simple protein precipitation. Dapoxetine-d(7) was selected as the internal standard. The established method was performed using a mass spectrometer equipped with an electrospray ionization source in multiple positive ion reactions to monitor the mode using the precursor-to-product ion transitions of m/z 306.2-157.2...
- Effect of a tadalafil 5-mg single daily dose on lifelong premature ejaculation: A single-blinded placebo-controlled studyby Amr Hassan Abou Faddan on May 9, 2022
CONCLUSIONS: Despite 5-mg tadalafil once daily being safe and it showed only a slight improvement in IELT and PEDT in the treatment of lifelong PE, failing to show any statistically significant difference from the placebo drug.Abbreviations: ED: erectile dysfunction; 5-HT: 5-hydroxytryptamine (serotonin); IELT: the intravaginal ejaculation latency time; ISSM: International Society of Sexual Medicine; PE: premature ejaculation; PEDT: Premature Ejaculation Diagnostic Tool; PDE5i:...
- Evaluation of toxicological safety and quality control of Luobufukebiri pillby Heng Wang on May 8, 2022
CONCLUSIONS: This study further confirmed the safety of Luobufukebiri pill in clinical practice. A rapid, accurate, and convenient RP-HPLC-PDA detection method has been developed for the simultaneous detection of eight active compounds in the pharmaceutical samples of Luobufukebiri pill. This study provided a reference for the safety and enhancement of the quality standards of Luobufukebiri pill.
- Nomogram for stratifying patients with lifelong premature ejaculation before using the PHQ-9: an observational studyby Guangdong Hou on May 6, 2022
CONCLUSION: A nomogram to discern LPE patients with low risks of PHQ-9^(+) was established. This tool can increase the positivity of MDD screening and may improve the therapeutic outcomes of those in the low-risk group.