Phencylidine
Phencyclidine or phenylcyclohexyl piperidine, also known as angel dust among other names, is a drug used for its mind-altering effects. PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected.
Cluster Number:
Wiki Number: PW165
Diagnosis: Phencyclidine-PCP Related Disorders
US Patients: 2017-3% used sometime in their lives; 36% moved on into schizophrenia.
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Inhibits hyppocampus, cerebellum with prolonged use leading to memory loss; acts like dopamine in its receptors
Symptoms: Drug “angel-dust” for mind-altering, hallucinations, muted sounds, violent behavior; may have adverse effects or suicide.
Progression: Unpredictable brain-altering in the short term; long-term brain damage often occurred. Resembles a schizophrenic episode.
Causes: used recreationally
Medications: benzodiazopenes for agitation and seizures; antipsychotics
Therapies: None listed.
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Synthesis and Antinociceptive activity of Newly Modified Amine analogs of Phencyclidine in Miceby Maryam Shokrollahi on October 6, 2021
CONCLUSION: It can be concluded that the methyl-piperazine analog of phencyclidine was the best candidate to decrease acute thermal and benzylamine derivatives were suitable candidates to reduce chemical pains.
- Test-retest reliability and cross-cultural applicability of DSM-5 adopted diagnostic criteria for ketamine use disordersby Nicole D Fitzgerald on September 30, 2021
CONCLUSIONS: Diagnoses of ketamine use disorder can be reliably evaluated using this fully structured diagnostic instrument's questions and algorithm. Ketamine-related withdrawal among people who use ketamine should be re-evaluated. Considering that after-effects of this dissociative anesthetic can last for many hours, it is important to explore a different timeframe for possible withdrawal effects.
- Does nicotine exposure during adolescence modify the course of schizophrenia-like symptoms? Behavioral analysis in a phencyclidine-induced mice modelby Ana Carolina Dutra-Tavares on September 29, 2021
The first symptoms of schizophrenia (SCHZ) are usually observed during adolescence, a developmental period during which first exposure to psychoactive drugs also occurs. These epidemiological findings point to adolescence as critical for nicotine addiction and SCHZ comorbidity, however it is not clear whether exposure to nicotine during this period has a detrimental impact on the development of SCHZ symptoms since there is a lack of studies that investigate the interactions between these...
- Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Miceby Rosa Estrada-Reyes on September 10, 2021
Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks to be effective with forty percent of patients being resistant to treatment, making it necessary to search for new antidepressant treatments. Ketamine, a phencyclidine hydrochloride derivative, given intravenously, induces a rapid antidepressant effect in humans. In mice, it causes increased neurogenesis and...