Phencylidine
Phencyclidine or phenylcyclohexyl piperidine, also known as angel dust among other names, is a drug used for its mind-altering effects. PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected.
Cluster Number:
Wiki Number: PW165
Diagnosis: Phencyclidine-PCP Related Disorders
US Patients: 2017-3% used sometime in their lives; 36% moved on into schizophrenia.
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Inhibits hyppocampus, cerebellum with prolonged use leading to memory loss; acts like dopamine in its receptors
Symptoms: Drug “angel-dust” for mind-altering, hallucinations, muted sounds, violent behavior; may have adverse effects or suicide.
Progression: Unpredictable brain-altering in the short term; long-term brain damage often occurred. Resembles a schizophrenic episode.
Causes: used recreationally
Medications: benzodiazopenes for agitation and seizures; antipsychotics
Therapies: None listed.
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4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent modelsby Anna Partyka on March 11, 2025
CONCLUSIONS: The complex pharmacodynamic profile translated into the useful psychotropic effects. While the compounds potentiated D-amphetamine- and phencyclidine-induced hyperactivity, this action could be regarded as a desired activating effect rather than evidence against antipsychotic-like efficacy. Present findings point to PZ-1262 as a more promising lead compound for further research.
- Toxicological and Demographic Profiles of Phencyclidine (PCP)-Impaired Driving Cases in Houston: Updates from the 2019-2023 Databy Dayong Lee on March 6, 2025
Phencyclidine (PCP) is a dissociative anesthetic harmful to road traffic safety as the drug may impair driving performance by inducing adverse effects such as sedation, ataxia, agitation, disorientation, and confusion. Houston Forensic Science Center (HFSC) previously reported toxicological and demographic characteristics of PCP-impaired driving cases in Houston from 2013 to 2018 and presently reports the 2019-2023 cases. The blood samples collected from suspect drivers were analyzed for alcohol...
- Simultaneous analysis of 203 drugs of abuse and metabolites in urine samples using liquid chromatography-tandem mass spectrometryby Sangeun Lee on March 5, 2025
The issue of drug abuse is increasingly becoming a significant concern worldwide. However, the simultaneous detection of a wide spectrum of drug of abuse (DOA), especially in biofluids, is challenging due to their diverse and varied physicochemical properties and matrix effects. Herein, we have developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous detection of 203 DOAs, including amphetamines, opiates, cathinones, phencyclidines, synthetic cannabinoids,...
- Relationship between increased binding potential of possible 5-HT2A receptors in the ventral hippocampus by subchronic phencyclidine and disturbed social interaction in rats: a PET study using 18F-altanserinby Eiichi Jodo on March 4, 2025
Subchronic administration of the psychotomimetic drug phencyclidine is known to exacerbate serotonin 5-HT2A receptor-relevant behavioral abnormalities. However, the effects of subchronic phencyclidine on 5-HT2A receptors remain unclear. Here, we investigated the effects of subchronic phencyclidine on the binding potential (BPND) of 5-HT2A receptors in the rat brain using positron emission tomography. Adult male Sprague-Dawley rats received intraperitoneal injection of either phencyclidine (10...