Phencylidine
Phencyclidine or phenylcyclohexyl piperidine, also known as angel dust among other names, is a drug used for its mind-altering effects. PCP may cause hallucinations, distorted perceptions of sounds, and violent behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected.
Cluster Number:
Wiki Number: PW165
Diagnosis: Phencyclidine-PCP Related Disorders
US Patients: 2017-3% used sometime in their lives; 36% moved on into schizophrenia.
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Inhibits hyppocampus, cerebellum with prolonged use leading to memory loss; acts like dopamine in its receptors
Symptoms: Drug “angel-dust” for mind-altering, hallucinations, muted sounds, violent behavior; may have adverse effects or suicide.
Progression: Unpredictable brain-altering in the short term; long-term brain damage often occurred. Resembles a schizophrenic episode.
Causes: used recreationally
Medications: benzodiazopenes for agitation and seizures; antipsychotics
Therapies: None listed.
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High-resoluton targeted stimulant and phencyclidine (PCP)
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4 CURRENT ARTICLES
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The world-wide medical research
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PubMed article’s summary-abstract.
- Qualitative confirmation of 30 phencyclidine analogs in human blood and urine using GC-HRMS and a self-built library searchby Zixuan Song on January 14, 2025
INTRODUCTION: Phencyclidine, a dissociative anesthetic with hallucinogenic effects, is commonly abused as a recreational drug. Phencyclidine analogs are compounds produced by substitutions of the phenyl and piperidine rings of phencyclidine. Illegal use of phencyclidine and its analogs has symptoms such as addiction, confusion, and increased tendencies toward violence. In this study, a novel high-throughput screening method was applied for GC-HRMS identification of 30 phencyclidine analogs in...
- A New Three-Hit Mouse Model of Neurodevelopmental Disorder with Cognitive Impairments and Persistent Sociability Deficitsby Imane Mouffok on January 8, 2025
CONCLUSIONS: Our work confirms the usefulness of a three-hit combination to model, particularly for negative-like symptoms associated with schizophrenia and other psychiatric disorders. The model therefore gathers powerful construct and face validities and supports an involvement of glutamate dysfunction in behavioral symptoms.
- Structure Confirmation of Three New Psychoactive Substances and Qualitative Identification of Unknown Substancesby Zong-Yang Nie on December 3, 2024
CONCLUSIONS: This study systematically summarizes the distinguishing features of the infrared absorption spectrometry, nuclear magnetic resonance spectroscopy and mass spectrometry of three NPSs, which can provide a reference for the qualitative identification of unknown substances.
- Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophreniaby Ruri Okubo on September 28, 2024
For several decades, the dopamine hypothesis contributed to the discovery of numerous typical and atypical antipsychotics and was the sole hypothesis for the pathophysiology of schizophrenia. However, neither typical nor atypical antipsychotics, other than clozapine, have been effective in addressing negative symptoms and cognitive impairments, which are indices for the prognostic and disability outcomes of schizophrenia. Following the development of atypical antipsychotics, the therapeutic...