Paranoid Personality Disorder

Paranoid personality disorder (PPD) is one of a group of conditions called “Cluster A” personality disorders which involve odd or eccentric ways of thinking. People with PPD also suffer from paranoia, an unrelenting mistrust and suspicion of others, even when there is no reason to be suspicious.


Cluster Number:
Wiki Number: PW151
Diagnosis: Paranoid Personality Disorder
US Patients: .5%-2.5% of the general population
World Patients:
Sex Ratio: M+;F
Age Onset:
Brain Area:
Symptoms: paranoid delusions, mistrust of others, constantly seeking validation of their fears and mistrust. Isolate themselves.
Progression: suspicious, preoccupied with friends’ loyalty, bears grudges, quick to attack and counterattack, fears spousal infidelity
Causes: heritable, overvalue their capabilities and attribute limitations or failures to the deviancy of others
Medications: antidepressants, antipsychotics and anti-anxiety medications


The world-wide medical research
reports chosen for each diagnosis 

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PubMed article’s summary-abstract.

  • Prevalence of Comorbid Personality Disorder in Psychotic and Non-psychotic Disorders
    by Qiang Wang on January 10, 2022

    Introduction: The burden of personality disorders (PDs) in China is large and the focus on mental health services is increasing. However, there is a lack of sufficient evidence regarding the prevalence of comorbid PD in psychotic and non-psychotic disorders, and whether PDs have different distributions. We aimed to investigate the PD comorbidity distribution pattern between psychotic and non-psychotic disorders using a clinical population-based study. Materials and Methods: We conducted a...

  • Personality Disorder
    by Kamron A. Fariba on January 1, 2022

    Temperament classification dates back as far as ancient Greece when Hippocrates proposed his humoral theory regarding the classifications of behavior. The postulated temperaments, consisting of sanguine, choleric, melancholic, and phlegmatic, remained in use as recently as the 20th century. Emil Kraepelin classified manic-depressive patients as depressive, hypomanic, or irritable, which in turn correlated with melancholic, sanguine, or choleric dispositions, respectively. These, in turn, evolved...

  • Schizoid Personality Disorder
    by Kamron A. Fariba on January 1, 2022

    In the 5th century B.C., Hippocrates first propounded his theory of humorism to describe the different temperaments. This idea postulated that human behavior could be categorized into four distinct temperaments, black bile, sanguine (blood), yellow bile, and phlegm, which in turn correlated with the four elements earth, air, fire, and water, respectively. Hippocrates further elaborated on his theory by describing black bile as melancholic, sanguine as optimistic, yellow bile as irritable and...

  • Avoidant Personality Disorder
    by Kamron A. Fariba on January 1, 2022

    In the 5th century B.C., Hippocrates offered his hypothesis regarding the origin of behavior with his humoral theory, postulating temperament was derived from the heterogeneous balance of the four distinct humors in the body. The four humors consisted of black bile - melancholic, yellow bile - irritable, phlegm - apathetic, and blood - sanguine. The humors and their subsequent temperaments supposedly embodied the elements of earth, fire, water, and air, respectively. References to this nascent...