Opioid Use Disorder
Wiki Number: PW144
Diagnosis: Opioid Use Disorder
US Patients: About 27 million in 2016
Sex Ratio: M+;F
Age Onset: Young adults
Brain Area: Opioids reduce dopamine in nucleus accumbens. Neuroimaging affects in the orbitofrontal area-reducing reward-behaviors
Symptoms: strong desire to use oioids, tolerance, withdrawal symptoms & living normal lives; most US heroin users began with prescriptions
Progression: Long term use shows dysregulation of brain circuits for emotion, distress and high impulsivity.
Medications: opioid replacement threrapy uses methadone or buprenophine and naltrexone; heroin withdrawal symptoms from 2 days-2 weeks
Therapies: CBT; Lohr’s “Calming My Pain!” (DVD or Download from this website) helps to retrain the brain to reduce pain without opioids.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Patient Activation of Persons With Opioid Use Disorder in Intensive Outpatient Treatmentby Alyson Keen on May 18, 2022
CONCLUSIONS: Patient activation is multidimensional and plays a salient role in IOT experiences. IOT staff should engage patients as active participants in their treatment and encourage mutual goal-setting and shared-decision but should be aware that some approaches used too early in treatment may impede recovery.
- Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Makingby Elissa R Weitzman on May 17, 2022
CONCLUSION: Positive responses to a fentanyl vaccine were found along with appreciation for the complexity of a vaccine strategy to prevent OD in the setting of pain and uncertain durability. Further research is needed to elucidate operational, ethical, and communications strategies to advance the model.
- Improving acute pain management of trauma patients on medication-assisted therapyby Kimberly D Broughton-Miller on May 17, 2022
CONCLUSIONS: Effective patient-centered acute pain control for trauma patients on MAT is achievable. The combined use of an SDM tool and a provider checklist was an efficient way to provide effective and patient-centered care and positively affected patient outcomes.
- Cannabidiol in the context of substance use disorder treatment: A systematic reviewby Victoria Paulus on May 17, 2022
CONCLUSIONS: CBD might offer promising therapeutic potential for the treatment of SUD, especially for nicotine, cannabis, and opioid use disorders, based on available human studies. The available research evidence is, however, sparse and more research on humans is needed.