Wiki Number: PW143
Diagnosis: Opioid Overdose
US Patients: 110,000 deaths + more with permanent brain damage (2017)
World Patients: 500,000 deaths, world wide
Brain Area: inadequate oxygen in the brain in the medulla and pons can lead to death or brain damage
Symptoms: Inability to breathe or decreased consciousness can kill.
Medications: Naloxone has reversed more than 25,000 overdoses by 2014.
Therapies: Used as directed, Lohr’s DVD and Download, “Calming My Pain!” avoidusing opioids for post-surgical or other causes of pain.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Are People Who Die by Intentional Medication Poisoning Dispensed Those Medications in the Year Prior to Death?by Jennifer M Boggs on May 17, 2022
CONCLUSIONS: Our results indicate that most medications used in suicidal overdose were likely recently dispensed. Therefore, future suicide prevention studies and prevention resources should focus on medication safety interventions such as lethal-means counseling for medication access, limiting quantities dispensed, opioid antagonists, and blister packs. HIGHLIGHTSUnderstanding whether medications used for self-poisoning were recently dispensed or formerly/never dispensed would help inform...
- Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Makingby Elissa R Weitzman on May 17, 2022
CONCLUSION: Positive responses to a fentanyl vaccine were found along with appreciation for the complexity of a vaccine strategy to prevent OD in the setting of pain and uncertain durability. Further research is needed to elucidate operational, ethical, and communications strategies to advance the model.
- Comparing person-level matching algorithms to identify risk across disparate datasets among patients with a controlled substance prescription: retrospective analysisby Lindsey M Ferris on May 16, 2022
CONCLUSIONS: Our study illustrates the specific tradeoffs of different matching methods. Further research should be performed to compare matching algorithms and its impact on the prevalence of key risk indicators in an applied setting that can improve understanding of risk within a population.
- Potential Impact of 3% Hypertonic Saline Infusion on Tramadol Poisoning-Induced Electrocardiogram Changes; a Randomized Clinical Trialby Ali Omraninava on May 16, 2022
CONCLUSION: Given that hypertonic saline infusion can significantly ameliorate tramadol-mediated ECG changes, including QRS prolongation and QT lengthening, it can be regarded as a potential therapeutic strategy to prevent the development of life-threatening ventricular arrhythmias caused by tramadol toxicity.