Obsessive-Compulsive Disorder
Cluster Number:
Wiki Number: PW138
Diagnosis: Obsessive-Compulsive Disorder
US Patients: 1.2% at a given time
World Patients:
Sex Ratio:
Age Onset: before age 35
Brain Area: smaller dorsolateral prefrontal cortex is only one part of the brain apparently involved. Nucleus accumbens stimulation has helped.
Symptoms: out-of-control routines with repeated thoughts-obessions; repeated actions-compulsions; sex, organization, cleaning, hoarding
Progression:
Causes: genetic affected by several different genes; depression, drug use, anxiety
Medications: antidepressants, SSRIs,
Therapies: CBT may help, but there are insufficient studies proving its worth.
Youtube Video: Obsessive Compulsive Disorder
Amazon or Library Book: Standing Up to OCD: Workbook for Kids
Amazon or Library Book:
Rewire Your OCD Brain
Click the book to link or order from Amazon.
Click the book to link or order from Amazon.
Support Group: iocdf.org; 617-973-5801
(International OCD Foundation
– This website includes a meeting directory.)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Visuospatial working memory capacity moderates the relationship between anxiety and OCD related checking behaviorsby Pengchong Wang on January 26, 2023
CONCLUSION: Anxiety symptoms play an important role in explaining compulsive checking behavior in patients with OCD who have relatively weak visuospatial working memory ability. These findings provide a foundation for further research regarding the roles of emotion and cognitive inflexibility in compulsive checking behavior in patients with OCD.
- Monoamine Oxidase Inhibitors for Trichotillomania: A Case Seriesby Jon E Grant on January 26, 2023
PURPOSE/BACKGROUND: Despite several decades of research, there are no US Food and Drug Administration-approved medications for trichotillomania or medications generally approved in other geographical jurisdictions. Monoamine oxidase inhibitors show efficacy in the treatment of depression and some possible promise for obsessive compulsive disorder.
- Cholinergic neurons in the basal forebrain are involved in behavioral abnormalities associated with Cul3 deficiency: Role of prefrontal cortex projections in cognitive deficitsby Maximiliano Rapanelli on January 24, 2023
Loss-of-function mutations of the gene Cul3 have been identified as a risk factor for autism-spectrum disorder (ASD), but the pathogenic mechanisms are not well understood. Conditional Cul3 ablation in cholinergic neurons of mice (Chat^(CRE)Cul3^(F/+)) recapitulated ASD-like social and sensory gating phenotypes and caused significant cognitive impairments, with diminished activity of cholinergic neurons in the basal forebrain (BF). Chemogenetic inhibition of BF cholinergic neurons in healthy...
- Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disordersby Minoru Hatayama on January 23, 2023
SLITRK1 is a neuronal transmembrane protein with neurite development-and synaptic formation-controlling abilities. Several rare variants of SLITRK1 have been identified and implicated in the pathogenesis of Tourette's syndrome, trichotillomania, and obsessive-compulsive disorder, which can be collectively referred to as obsessive-compulsive-spectrum disorders. Recent studies have reported a possible association between bipolar disorder and schizophrenia, including a revertant of modern...