Obsessive-Compulsive Disorder
Cluster Number:
Wiki Number: PW138
Diagnosis: Obsessive-Compulsive Disorder
US Patients: 1.2% at a given time
World Patients:
Sex Ratio:
Age Onset: before age 35
Brain Area: smaller dorsolateral prefrontal cortex is only one part of the brain apparently involved. Nucleus accumbens stimulation has helped.
Symptoms: out-of-control routines with repeated thoughts-obessions; repeated actions-compulsions; sex, organization, cleaning, hoarding
Progression:
Causes: genetic affected by several different genes; depression, drug use, anxiety
Medications: antidepressants, SSRIs,
Therapies: CBT may help, but there are insufficient studies proving its worth.
Youtube Video: Obsessive Compulsive Disorder
Amazon or Library Book: Standing Up to OCD: Workbook for Kids
Amazon or Library Book:
Rewire Your OCD Brain
Click the book to link or order from Amazon.
Click the book to link or order from Amazon.
Support Group: iocdf.org; 617-973-5801
(International OCD Foundation
– This website includes a meeting directory.)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Genome-wide association study identifies 30 obsessive-compulsive disorder associated lociby Nora I Strom on May 7, 2024
Obsessive-compulsive disorder (OCD) affects ∼1% of the population and exhibits a high SNP-heritability, yet previous genome-wide association studies (GWAS) have provided limited information on the genetic etiology and underlying biological mechanisms of the disorder. We conducted a GWAS meta-analysis combining 53,660 OCD cases and 2,044,417 controls from 28 European-ancestry cohorts revealing 30 independent genome-wide significant SNPs and a SNP-based heritability of 6.7%. Separate GWAS for...
- A cross ancestry genetic study of psychiatric disorders from Indiaby Bharath Holla on May 7, 2024
Genome-wide association studies across diverse populations may help validate and confirm genetic contributions to risk of disease. We estimated the extent of population stratification as well as the predictive accuracy of polygenic scores (PGS) derived from European samples to a data set from India. We analysed 2685 samples from two data sets, a population neurodevelopmental study (cVEDA) and a hospital-based sample of bipolar affective disorder (BD) and obsessive-compulsive disorder (OCD)....
- The relationship between cognitive phenotypes of compulsivity and impulsivity and clinical variables in obsessive-compulsive disorder: A systematic review and Meta-analysisby Aaron T Clarke on May 7, 2024
CONCLUSION: Cognitive phenotypes of compulsivity and impulsivity in patients with OCD appear to be orthogonal to clinical variables, including severity of OCD symptomatology. Their clinical impact is poorly understood and may require different clinical assessment tools and interventions.
- An exploration of neural predictors of treatment compliance in cognitive-behavioral group therapy for hoarding disorderby Blaise L Worden on May 6, 2024
A persistent and influential barrier to effective cognitive-behavioral therapy (CBT) for patients with hoarding disorder (HD) is treatment retention and compliance. Recent research has suggested that HD patients have abnormal brain activity identified by functional magnetic resonance (fMRI) in regions often engaged for executive functioning (e.g., right superior frontal gyrus, anterior insula, and anterior cingulate), which raises questions about whether these abnormalities could relate to...