Obsessive-Compulsive Disorder
Cluster Number:
Wiki Number: PW138
Diagnosis: Obsessive-Compulsive Disorder
US Patients: 1.2% at a given time
World Patients:
Sex Ratio:
Age Onset: before age 35
Brain Area: smaller dorsolateral prefrontal cortex is only one part of the brain apparently involved. Nucleus accumbens stimulation has helped.
Symptoms: out-of-control routines with repeated thoughts-obessions; repeated actions-compulsions; sex, organization, cleaning, hoarding
Progression:
Causes: genetic affected by several different genes; depression, drug use, anxiety
Medications: antidepressants, SSRIs,
Therapies: CBT may help, but there are insufficient studies proving its worth.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
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PubMed article’s summary-abstract.
- Adverse childhood experiences in patients with severe health anxiety: No evidence for an increased frequency compared to patients with obsessive-compulsive disorderby Tine B Gehrt on July 2, 2022
Theoretical models of health anxiety emphasize adverse childhood experiences in the development of the disorder, but few studies examine such events in patients with severe health anxiety and the results are difficult to compare across studies. The present study examined adult retrospective reports of illness-related and traumatic childhood experiences in 31 patients with severe health anxiety, 32 non-clinical control participants, and a clinical control group of 33 patients with...
- Exposure and Response Prevention in Virtual Reality for Patients with Contamination-Related Obsessive-Compulsive Disorder: a Case Seriesby Franziska Miegel on July 2, 2022
Exposure therapy in virtual reality is successful in treating anxiety disorders. Studies on exposure and response prevention in virtual reality (VERP) in obsessive-compulsive disorder (OCD) are rare, and it is unclear whether distress associated with other emotions than anxiety (e.g., disgust) can be evoked. The present study aimed to investigate whether distress can be induced during VERP in patients with contamination-related OCD (C-OCD) and a primary feeling of disgust. We treated eight...
- Serum Claudin-5, but not Zonulin, May Be Associated with Obsessive-Compulsive Disorderby Faruk Kılıç on June 30, 2022
CONCLUSIONS: In conclusion, the current research indicates that claudin-5 is enhanced in OCD patients and this finding may contribute to the role of blood-brain barrier in the pathogenesis of OCD.
- Dopamine-transporter heterozygous rats carrying maternal wild-type allele are more vulnerable to the development of compulsive behaviorby Fabiana Festucci on June 30, 2022
Compulsivity is defined as an unstoppable tendency towards repetitive and habitual actions, which are reiterated despite negative consequences. Polydipsia is induced preclinically by intermittent reward leading rodents to ingest large amounts of fluids. We focused on the role of dopamine transporter (DAT) and inheritance factors in compulsive behavior. Our sample consisted of DAT heterozygous (HET) rats with different genetic inheritance (MAT-HET, born from WT-dams x KO-fathers; MIX-HET, born...