Wiki Number: PW138
Diagnosis: Obsessive-Compulsive Disorder
US Patients: 1.2% at a given time
Age Onset: before age 35
Brain Area: smaller dorsolateral prefrontal cortex is only one part of the brain apparently involved. Nucleus accumbens stimulation has helped.
Symptoms: out-of-control routines with repeated thoughts-obessions; repeated actions-compulsions; sex, organization, cleaning, hoarding
Causes: genetic affected by several different genes; depression, drug use, anxiety
Medications: antidepressants, SSRIs,
Therapies: CBT may help, but there are insufficient studies proving its worth.
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout miceby Gwynne L Davis on October 16, 2021
Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto-striatal circuits. There are currently no fast-acting pharmacological treatments for OCD. However, recent clinical studies demonstrated that an intravenous infusion of ketamine rapidly reduces OCD symptoms. To probe mechanisms underlying ketamine's therapeutic effect on OCD-like behaviors, we used the SAPAP3 knockout (KO) mouse...
- Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspectsby Subhabrata Paul on October 15, 2021
Withania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative properties against a plethora of human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents. In addition, it presents a...
- Editorial: Invasive Treatments for Obsessive Compulsive Disorderby Marshall T Holland on October 15, 2021
- Clinical Features in Patients With PANDAS/PANS and Therapeutic Approaches: A Retrospective Studyby Isabella Rea on October 15, 2021
Objective: The clinical characteristics of patients with PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) and PANS (pediatric acute-onset neuropsychiatric syndrome) and the efficacy of antibiotic therapy with psychotherapy and antipsychotics were investigated to improve neurological symptoms as well as obsessive compulsive disorder (OCD). Methods: We retrospectively analyzed 62 patients with a clinical diagnosis of PANDAS/PANS enrolled from May 14,...