Nicotine Withdrawal
Millions of people know from personal experience that smoking is a tough habit to kick. The reason is that nicotine is addictive. Even though nicotine’s high isn’t as dramatic as cocaine or heroin’s, it’s equally as addictive as those illegal drugs.
And nicotine withdrawal is very real. It’s why so many smokers try many times before they finally quit for good.
Nicotine affects all areas of your body, from your heart and blood vessels to your hormones, metabolism, and brain. When you don’t have it anymore, you go through withdrawal. You’ll physically crave that nicotine hit and become irritable if you can’t have it.
Nicotine withdrawal usually lasts only a month or so, but you could be fighting the mental battle against cigarettes for a long time.
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Brain Area: binding to nicotinic receptors in the brain, increasing dopamine; opiate, serotonic, glutamic and other receptors apply in withdrawal
Symptoms: nicotine cravings, irritability, anxiety and difficulty concentrating; symptoms usually disappear after four weeks.
Progression:
Causes: genetics may affect the severity of withdrawal
Medications: several medications can be used
Therapies: increased exercise, avoiding “smoking situations,” avoiding temptations, friend-support
Youtube Video: 72 Hours of Nicotine Withdrawal
Amazon or Library Books:
Easy Way to Quit Smoking
Easy Way to Quit Vaping
Click the book to link or order from Amazon.
Click the book to link or order from Amazon.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Rational Design of a Flavoenzyme for Aerobic Nicotine Catabolismby Haiyang Hu on July 19, 2024
Enzymatic therapy with nicotine-degrading enzyme is a new strategy in treating nicotine addiction, which can reduce nicotine concentrations and weaken withdrawal in the rat model. However, when O(2) is used as the electron acceptor, no satisfactory performance has been achieved with one of the most commonly studied and efficient nicotine-catabolizing enzymes, NicA2. To obtain more efficient nicotine-degrading enzyme, we rationally designed and engineered a flavoenzyme Pnao, which shares high...
- Chemogenetic control of GABAergic activity within the interpeduncular nucleus reveals dissociable behavioral components of the nicotine withdrawal phenotypeby Anabel M M Miguelez Fernández on July 19, 2024
Chronic exposure to nicotine results in the development of a dependent state such that a withdrawal syndrome is elicited upon cessation of nicotine. The habenulo-interpeduncular (Hb-IPN) circuit contains a high concentration of nAChRs and has been identified as a main circuit involved in nicotine withdrawal. Here we investigated the contribution of two distinct subpopulations of IPN GABAergic neurons to nicotine withdrawal behaviors. Using a chemogenetic approach to specifically target...
- Impact of Heating Conventional Cigarettes with a Novel Device on Health-related Biomarkers and Cigarette Use Patterns among Chinese Adult Smokers Unwilling to Quit: A Pilot Randomized Controlled Trialby Shuilian Chu on July 18, 2024
CONCLUSIONS: Switching to heated cigarettes with the HTP device may reduce short-term exposure to smoke toxicants. However, it can lead to increased tobacco use among dual users. Further investigation is needed to confirm these preliminary findings.
- Blunted midbrain reward activation during smoking withdrawal: a preliminary studyby A A Conti on July 17, 2024
INTRODUCTION: Tobacco smoking is the leading preventable cause of death, causing more than six million deaths annually worldwide, mainly due to cardiovascular disease and cancer. Many habitual smokers try to stop smoking but only about 7% are successful, despite widespread knowledge of the risks. Development of addiction to a range of substances is associated with progressive blunting of brain reward responses and sensitisation of stress responses, as described by the allostasis theory of...