Neuroleptic Malignant Syndrome
NEEDS IMMEDIATE MEDICAL ATTENTION!
Neuroleptic malignant syndrome (NMS) is a life-threatening idiosyncratic reaction to antipsychotic drugs characterized by fever, altered mental status, muscle rigidity, and autonomic dysfunction.
Cluster Number:
Wiki Number: PW132
Diagnosis: Neuroleptic Malignant Syndrome-NEEDS IMMEDIATE MEDICAL ATTENTION!
US Patients:
World Patients:
Sex Ratio: M+;F
Age Onset:
Brain Area:
Symptoms: increased body temperature, confusion, sweating, rigid muscles, antonomic imbalance: can be fatal within 3 days!
Progression: TOO COMPLEX TO SUMMARIZE HERE!
Causes: Responses to neuroleptic or antipsychotic medicines – 10% CAN BE FATAL! (Includes rapid decrease in “L-Dopa” used for Parkinson’s)
Medications:
Therapies:
Youtube Video: Neuroleptic Malignant Syndrome
Amazon or Library Book:
Neuroleptic Malignant Syndrome and Related Conditions
Click the book to link or buy from Amazon.
Support Group: nmsis.org; 607-674-7920
(Neuroleptic Malignant Syndrome Information Service, Inc.)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Paliperidone-induced neuroleptic malignant syndrome: A case reportby Gonca Ayse Unal on March 11, 2025
RATIONALE: Neuroleptic malignant syndrome (NMS) is a rare, life-threatening complication of neuroleptic (antipsychotic) medications. Paliperidone is an atypical antipsychotic used in the treatment of schizophrenia. While current evidence suggests that atypical oral antipsychotics have a lower incidence of NMS compared to typical oral antipsychotics, there is limited information available on the incidence and management of NMS associated with long-acting injectable (LAI) antipsychotics. More case...
- A case of modified electroconvulsive therapy for a patient with dementia with Lewy bodies and neuroleptic malignant syndromeby Takato Yokoi on March 4, 2025
No abstract
- Second-Generation Antipsychotic-Associated Serious Adverse Events in Women: An Analysis of a National Pharmacoepidemiologic Databaseby Kenneth L McCall on February 27, 2025
CONCLUSIONS: Our findings suggest higher odds of TdP and worse TdP-associated outcomes among females exposed to SGAs compared to males. Further studies are needed to confirm these preliminary findings.
- Paliperidone-Induced Massive Asymptomatic Creatine Kinase Elevation in Youth: From a Case Report to Literature Reviewby Aurora Grandioso on February 25, 2025
CONCLUSIONS: Making a MACKE diagnosis is essential since its relevant clinical and economic implications are mainly related to unnecessary closer laboratory monitoring or therapeutic changes (e.g., drug discontinuation or switch to another medication).