Narcolepsy

A chronic sleep disorder that causes overwhelming daytime drowsiness.
The cause of narcolepsy isn’t well understood but may involve genetic factors and abnormal signaling in the brain.

Narcolepsy causes sudden attacks of sleep. Sudden loss of muscle tone and hallucinations might occur.

Stimulants, antidepressants, and other medications can help.

 

Cluster Number:
Wiki Number: PW130
Diagnosis: Narcolepsy
US Patients: Estimated to affect 200,000, but only 50,000 diagnosed.
World Patients:
Sex Ratio:
Age Onset: Adolescence and early adulthood
Brain Area:
Symptoms: Inability to regulate poor-quality sleep-wake cycles and brief, involuntary sleeping; 70% have catalepsy-sudden muscle weakness;
Progression: The Wikipedia article lists a number of genes and chromosomes regulating sleep, too complex for this overview.
Causes: family history 10%; loss of orexin neurons (which regulate sleep and wakefulness) in the lateral hypothalamus
Medications: Several other medications are being developed.
Therapies: regular short naps & sleep-hygiene=quiet bedroom, bed for sleep and sex only; regular bedtimes.

Youtube Video: What is Narcolepsy?

Amazon or Library Book:

My Dad Naps, Too!

Amazon or Library Book:

Waking Mathilda

Click the book to link or buy from Amazon.

Click the book to link or buy from Amazon.

Support Group: narcolepsynetwork.org; 401-667-2523

(Narcolepsy Network, Inc.)

4 CURRENT ARTICLES
FROM PUBMED

The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • NLS-3 (Levophacetoperane or (R,R) Phacetoperane): A Reverse Ester of Methylphenidate: A Literature Review
    by Eric Konofal on January 23, 2023

    CONCLUSION: NLS-3 could be a safer and more potent alternative to stimulants for patients with ADHD.

  • Remote Teaching and School Refusal Behavior - Lessons Learned from the COVID-19 Pandemic
    by Ulla Irene Hansen on January 23, 2023

    When the Norwegian government closed down schools and kindergartens in response to the increased spread of COVID-19, the use of homeschooling raised concerns about students with school refusal behavior and the school system's ability to address their special needs in these circumstances. Six students referred to the school absenteeism team were interviewed about their circumstances, using an author-developed interview. The results indicate that the students rated homeschooling as very...

  • Resilience and its correlates in patients with narcolepsy type 1
    by Alessandra D'Alterio on January 23, 2023

    CONCLUSIONS: The results of this study suggest that resilience may play a key role in patients' adaptation to NT1. Furthermore, this study supports interventions aimed at increasing patients' resilience, and provides a base for further studies, preferably longitudinal and including objective measures, directed toward understanding the relationship between resilience, depression and QoL in patients with narcolepsy.

  • Psychotic Episode and Schizophrenia in Slovakian Narcolepsy Database
    by Eva Feketeov√° on January 21, 2023

    Narcolepsy type 1 (NT1), a central disorder of hypersomnolence, is associated with mood, anxiety or hyperactivity mental disorders. Association with psychotic episode or schizophrenia is rare and could be the source of diagnostic and therapeutic difficulties. Their frequency in the national narcolepsy database has not been systematically studied. The aim of the presented study was to calculate the frequency of NT1 patients diagnosed with psychosis and/or schizophrenia, to identify clinical...