A chronic sleep disorder that causes overwhelming daytime drowsiness.
The cause of narcolepsy isn’t well understood but may involve genetic factors and abnormal signaling in the brain.
Narcolepsy causes sudden attacks of sleep. Sudden loss of muscle tone and hallucinations might occur.
Stimulants, antidepressants, and other medications can help.
Wiki Number: PW130
US Patients: Estimated to affect 200,000, but only 50,000 diagnosed.
Age Onset: Adolescence and early adulthood
Symptoms: Inability to regulate poor-quality sleep-wake cycles and brief, involuntary sleeping; 70% have catalepsy-sudden muscle weakness;
Progression: The Wikipedia article lists a number of genes and chromosomes regulating sleep, too complex for this overview.
Causes: family history 10%; loss of orexin neurons (which regulate sleep and wakefulness) in the lateral hypothalamus
Medications: Several other medications are being developed.
Therapies: regular short naps & sleep-hygiene=quiet bedroom, bed for sleep and sex only; regular bedtimes.
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457by Yasuyuki Kimura on October 15, 2021
CONCLUSION: The target engagement of enerisant was demonstrated in the brains of living human subjects. The occupancy of histamine H(3) receptors by enerisant at 2 h can be predicted by applying the plasma concentration of enerisant to Hill's plot. The preliminary time-course investigation showed persistently high brain occupancy with high doses of enerisant despite the decreasing plasma concentration of the drug. Five milligrams or less dose would be appropriate for the treatment for narcolepsy...
- Greenness Assessment of Two Validated Stability Indicating Chromatographic Methods for Estimating Modafinil Using Analytical Eco-Scaleby Soha G Elsheikh on October 9, 2021
CONCLUSIONS: The proposed methods were validated according to ICH guidelines and were applied on bulk powder and pharmaceutical dosage form using eco-friendly mobile phases as the worldwide trend.
- Narcolepsy treatment in Sweden: An observational studyby Helena Gauffin on October 6, 2021
CONCLUSIONS: This study gives valuable information on pharmaceutical treatments and healthcare utilization for patients with narcolepsy and can be used to estimate the healthcare cost in the future. Patients with sodium oxybate treatment had more outpatient visits than other patients before and during treatment which may be due to the need to monitor potentially severe side-effects or may indicate that patients with sodium oxybate treatment have a severe disease. The number of included patients...
- Long-term effects of solriamfetol on quality of life and work productivity in participants with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apneaby Terri E Weaver on October 4, 2021
CONCLUSIONS: Long-term solriamfetol treatment was associated with clinically meaningful, sustained improvements in functional status, work productivity, and quality of life for up to 52 weeks. Adverse events were similar between narcolepsy and OSA.