Narcolepsy
A chronic sleep disorder that causes overwhelming daytime drowsiness.
The cause of narcolepsy isn’t well understood but may involve genetic factors and abnormal signaling in the brain.
Narcolepsy causes sudden attacks of sleep. Sudden loss of muscle tone and hallucinations might occur.
Stimulants, antidepressants, and other medications can help.
Cluster Number:
Wiki Number: PW130
Diagnosis: Narcolepsy
US Patients: Estimated to affect 200,000, but only 50,000 diagnosed.
World Patients:
Sex Ratio:
Age Onset: Adolescence and early adulthood
Brain Area:
Symptoms: Inability to regulate poor-quality sleep-wake cycles and brief, involuntary sleeping; 70% have catalepsy-sudden muscle weakness;
Progression: The Wikipedia article lists a number of genes and chromosomes regulating sleep, too complex for this overview.
Causes: family history 10%; loss of orexin neurons (which regulate sleep and wakefulness) in the lateral hypothalamus
Medications: Several other medications are being developed.
Therapies: regular short naps & sleep-hygiene=quiet bedroom, bed for sleep and sex only; regular bedtimes.
Youtube Video: What is Narcolepsy?
Amazon or Library Book:
My Dad Naps, Too!
Amazon or Library Book:
Waking Mathilda
Click the book to link or buy from Amazon.
Click the book to link or buy from Amazon.
Support Group: narcolepsynetwork.org; 401-667-2523
(Narcolepsy Network, Inc.)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Bibliometric and visual study of narcolepsy from 2000 to 2023by Chao Yang on December 20, 2024
CONCLUSION: In conclusion, the main research hotspots and frontiers in the field of narcolepsy are the diagnosis of narcolepsy, pathological mechanism of narcolepsy and the treatment of narcolepsy. More studies are needed to explore effective strategies for the diagnosis and treatment of narcolepsy.
- Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neuronsby Jace Jones-Tabah on December 19, 2024
No abstract
- Impaired Vigilance in Patients with Narcolepsy Type 1: A Psychomotor Vigilance Task Studyby Jiaqin Yu on December 18, 2024
CONCLUSION: More severe sleepiness and an increased emotional burden could underlie the arousal and vigilance deficits seen in patients with NT1. We speculate that impaired vigilance in patients with NT1 is associated with abnormal brain function caused by a resource allocation imbalance related to hypothalamic orexin neuron damage, sleep inertia may also have a slight impact on this. Future studies should delve into this topic more deeply.
- Combining Topic Modeling, Sentiment Analysis, and Corpus Linguistics to Analyze Unstructured Web-Based Patient Experience Data: Case Study of Modafinil Experiencesby Julia Walsh on December 11, 2024
CONCLUSIONS: This study demonstrated the value of combining NLP with linguistic techniques for analyzing large unstructured text datasets. Despite varying opinions, findings were methodologically consistent and challenged existing clinical evidence. This suggests that patient-generated data could potentially provide valuable insights into treatment outcomes, potentially improving clinical understanding and patient care.