Cluster Number:
Wiki Number: PW130
Diagnosis: Narcolepsy
US Patients: Estimated to affect 200,000, but only 50,000 diagnosed.
World Patients:
Sex Ratio:
Age Onset: Adolescence and early adulthood
Brain Area:
Symptoms: Inability to regulate poor-quality sleep-wake cycles and brief, involuntary sleeping; 70% have catalepsy-sudden muscle weakness;
Progression: The Wikipedia article lists a number of genes and chromosomes regulating sleep, too complex for this overview.
Causes: family history 10%; loss of orexin neurons (which regulate sleep and wakefulness) in the lateral hypothalamus
Medications: Several other medications are being developed.
Therapies: regular short naps & sleep-hygiene=quiet bedroom, bed for sleep and sex only; regular bedtimes.

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