Narcolepsy
Cluster Number:
Wiki Number: PW130
Diagnosis: Narcolepsy
US Patients: Estimated to affect 200,000, but only 50,000 diagnosed.
World Patients:
Sex Ratio:
Age Onset: Adolescence and early adulthood
Brain Area:
Symptoms: Inability to regulate poor-quality sleep-wake cycles and brief, involuntary sleeping; 70% have catalepsy-sudden muscle weakness;
Progression: The Wikipedia article lists a number of genes and chromosomes regulating sleep, too complex for this overview.
Causes: family history 10%; loss of orexin neurons (which regulate sleep and wakefulness) in the lateral hypothalamus
Medications: Several other medications are being developed.
Therapies: regular short naps & sleep-hygiene=quiet bedroom, bed for sleep and sex only; regular bedtimes.
Youtube Video: What is Narcolepsy?
Amazon or Library Book:
My Dad Naps, Too!
Amazon or Library Book:
Waking Mathilda
Click the book to link or buy from Amazon.
Click the book to link or buy from Amazon.
Support Group: narcolepsynetwork.org; 401-667-2523
(Narcolepsy Network, Inc.)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Isolated cataplexy without subjective and objective sleepiness in a hypocretin-deficient patient-is it narcolepsy?by Knar Gevorgyan on April 4, 2025
No abstract
- Risk of cardiovascular disease in people with narcolepsy: a plain language summary of publicationby Jed Black on April 3, 2025
No abstract
- Clinical and objective correlates of disrupted nighttime sleep in pediatric narcolepsy type 1by Lucie Barateau on April 3, 2025
CONCLUSION: DNS complaint in pediatric NT1 is frequent, associated with disease severity, but with few PSG markers in untreated condition. It improves in one third of patients after management. Further studies are needed to determine optimal measures of DNS in narcolepsy across ages, to be implemented in the management strategy.
- Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristicsby Derar Omari on March 31, 2025
CONCLUSIONS: The study demonstrates that microwave energy effectively alters the crystalline structure of modafinil in the presence of Gelucire^(®) 48/16, enhancing its amorphousness, compressibility, and compatibility. These findings highlight the potential of microwave-assisted complexation as a novel approach to improve the pharmaceutical performance of BCS Class II drugs like modafinil.