Minor depressive disorder

The essential feature of minor depressive disorder includes one or more depressive episodes that mimic a major depressive episode in length, but fewer symptoms are present and there is less impairment than in major depression. A depressive episode must involve either a sad or depressed mood or loss of interest in almost all previously enjoyed activities.


Cluster Number:
Wiki Number: PW122
Diagnosis: Minor Depressive Disorder
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area:
Symptoms: 2 of 4 depression symptoms for 2 weeks:loss of interest, depressed mood; insomnia, weight loss, feel worthless, suicidal thoughts
Progression: The Diagnostic and Statistical Manual of the American Psychological Association, 5th ed., 2013 no longer includes this diagnosis.
Medications: antidepressants
Therapies: CBT


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Relating neurosteroid modulation of inhibitory neurotransmission to behaviour
    by Delia Belelli on October 13, 2021

    Studies in the 1980s revealed endogenous metabolites of progesterone and deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the GABA(A) receptor (GABA(A) R). The discovery that such steroids are locally synthesised in the central nervous system (CNS) promoted the thesis that neural inhibition in the CNS may be "fine-tuned" by these neurosteroids to influence behaviour. In preclinical studies, these neurosteroids exhibited anxiolytic, anticonvulsant, analgesic...

  • Depression, Nutrition, and Adherence to Antiretroviral Therapy in Men Who Have Sex With Men in Manila, Philippines
    by Hend Elsayed on October 8, 2021

    Introduction: Depression is the most frequently observed psychiatric disorder among HIV patients. The effect of depression on adherence among men who have sex with men (MSM) HIV patients has not been well studied in the Philippines. Depression is commonly undiagnosed and consequently untreated, which leads to a negative influence on antiretroviral therapy (ART) adherence. Other risk factors such as HIV-related stigma, self-body image satisfaction, and nutritional status are recognized as...

  • The association of social factors and COVID-19-related resource loss with depression and anxiety among Arabs in Israel
    by Shira Pagorek-Eshel on October 7, 2021

    CONCLUSION: Mental health is embedded in dynamic sociopolitical contexts. Arabs as a national minority in Israel have a perceived sense of social exclusion and discrimination and social and material resource deprivation, which relates to their vulnerability, especially in the face of crisis. It is our obligation as researchers and practitioners to illuminate the centrality of these oppressive mechanisms in shaping mental health vulnerability. Clinical Impact Statement: The present study suggests...

  • The Moderating Role of Race and Ethnicity in the Relationship Between Negative Family Interactions and Mental Health Among Older Adults
    by Fei Wang on October 6, 2021

    BACKGROUND AND OBJECTIVES: Studies generally show that negative social interactions are detrimental to mental health for older adults. Further, empirical evidence suggests that negative interactions may function differently in relation to mental health across racial/ethnic groups given their unique life circumstances and social conditions. This study examines whether the association between negative family interactions and mental health outcomes varies by race and ethnicity.