Major Depressive Episode

Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems. You may have trouble doing normal day-to-day activities, and sometimes you may feel as if life isn’t worth living.

More than just a bout of the blues, depression isn’t a weakness and you can’t simply “snap out” of it. Depression may require long-term treatment. But don’t get discouraged. Most people with depression feel better with medication, psychotherapy or both.


Cluster Number:
Wiki Number: PW116
Diagnosis: Major Depressive Episode
US Patients: If untreated can last for several months to two years. Symptoms may improve within 6-8 weeks with treatment.
World Patients:
Sex Ratio: M+;F
Age Onset: Ages 20-45
Brain Area:
Symptoms: Symptoms for two weeks of major depressive disorder: loss of interest or pleasure, anxiety, insomnia
Progression: saddened mood, poor sleep, loss of energy, concentration or appetite, thoughts of death or suicide
Causes: Neurotransmitters out of balance, feeling worthless and dispairing; heredity or familial causes
Medications: antidepressants which take 4-6 weeks until maximum effect;
Therapies: psychotherapy

Youtube Video: Major Depressive Episode Self-Care Strategies

Amazon or Library Book:

Handbook of Depression in Children and Adolescents

Click the book to link or buy from Amazon. (Very Expensive!)

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Support; Online

(Anxiety & Depression Association of America)


The world-wide medical research
reports chosen for each diagnosis 

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PubMed article’s summary-abstract.