Major Depressive Disorder

A mental health disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.

Possible causes include a combination of biological, psychological, and social sources of distress. Increasingly, research suggests these factors may cause changes in brain function, including altered activity of certain neural circuits in the brain.

The persistent feeling of sadness or loss of interest that characterizes major depression can lead to a range of behavioral and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behavior, or self-esteem. Depression can also be associated with thoughts of suicide.

The mainstay of treatment is usually medication, talk therapy, or a combination of the two. Increasingly, research suggests these treatments may normalize brain changes associated with depression.

Cluster Number:
Wiki Number: PW115
Diagnosis: Major Depressive Disorder
US Patients:
World Patients: 163 Mil; 2% of world population
Sex Ratio: M;W2
Age Onset: 20s-30s; The average duration is 23 weeks, with three more during lifetime. ½ of patients will not have another episode.
Brain Area: 102 variations in the genome linked to depression; There is an extensive description of possible brain affects on depression.
Symptoms: Has at least two weeks of depressive mood; inability to enjoy pleasure; rumination; reduced sex drive, insomnia and hypersomnia
Progression: weight and appetite may be low; fatigue, social withdrawal, suicidal thoughts; delusions or sometimes hallucinations
Causes: 40%-hereditary; response to stressors, childhood abuse. The article claims general physicians miss 2/3 of depression diagnoses.
Medications: Antidepressants-for the deeply depressed; electroconvulsive therapy
Therapies: Counseling; transcranial magnetic stimulation, light therapy, exercise, light therapy,

CLICK HERE FOR THE FULL WIKIPEDIA ARTICLE

4 CURRENT ARTICLES
FROM PUBMED

The world-wide medical research
reports chosen for each diagnosis

Clicking each title opens the
PubMed article’s summary-abstract.

Dimensional (premenstrual symptoms screening tool) vs categorical (mini diagnostic interview, module U) for assessment of premenstrual disorders
by Rifka Chamali on May 18, 2022
CONCLUSION: This study confirms that the severity measures from PSST can recognize patients with moderate/ severe PMS and PMDD who would benefit from immediate treatment.
Effect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial
by Herriot Tabuteau on May 18, 2022
CONCLUSIONS: In patients with major depression, dextromethorphan-bupropion (AXS-05) significantly improved depressive symptoms compared with bupropion and was generally well tolerated.
Anterior default mode network and posterior insular connectivity is predictive of depressive symptom reduction following serial ketamine infusion
by Benjamin S C Wade on May 17, 2022
CONCLUSIONS: Our findings support that connectivity of the anterior default mode network and PoI may serve as potential biomarkers of antidepressant outcomes for core depressive symptoms.
Diabetes Mellitus Type 1 During the COVID 19: Psychological Symptoms and Eating Attitudes
by Emmanouil S Benioudakis on May 17, 2022
CONCLUSIONS: The findings suggested that obese T1D patients are at greater risk of developing psychological symptoms and an eating disorder is being triggered to reduce the negative psychological symptoms. The results of this study may guide targeted interventions among T1D patients.

Major Depressive Disorder

4 CURRENT ARTICLESFROM PUBMED

4 CURRENT ARTICLES
FROM PUBMED