Korsakoff’s Syndrome
Korsakoff’s syndrome is a disorder that primarily affects the memory system in the brain. It usually results from a deficiency of thiamine (vitamin B1), which may be caused by alcohol abuse, dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy.
Cluster Number:
Wiki Number: PW111
Diagnosis: Korsakoff’s Syndrome
US Patients: 12.5% of heavy drinkers
World Patients :
Sex Ratio:
Age Onset:
Brain Area: lack of thiamine in the brain along with prolonged use of alcohol; Wernicke encaplophathy may accompany it ; thalamus damage
Symptoms: amnesia, inventing memories, apathy, licak of insight, minimal conversation
Progression: specific “declarative” memories (events), but not procedural memories (bike-riding) can be lost
Causes: malnutrition and heavy drinking over time
Medications: adding dietary thiamine and/or Vitamin B,
Therapies:
Youtube Video: 2-Minute Neuroscience:
Wernicke-Korsakoff Syndrome
Amazon or Library Book: Korsakoff’s or Wernicke-Korsakoff Syndrome Explained.
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4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Sudden vision loss in pregnancy: Wernicke's encephalopathy in a patient with hyperemesis gravidarumby Soundhar M Subramanian on December 15, 2024
Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad. The sudden visual loss in both eyes can be attributed to acute optic neuropathy. Our case highlights a unique...
- Towards a Non-pharmacological Intervention on Apathy in Korsakoff's Syndrome: A Systematic Narrative Review Across Different Clinical Conditionsby Maud E G van Dorst on November 19, 2024
ABSTRACT: Apathy is a quantitative reduction of goal-directed activity, which can be observed in relation to behavior, cognition, emotions and social interaction. It is an invalidating behavioral symptom that is frequently present across different psychiatric conditions and neurocognitive disorders including Korsakoff's Syndrome (KS). In fact, apathy is one of the most severe behavioral symptoms of KS and has a major impact on the lives of patients and their relatives and other informal...
- Social norms in Korsakoff's syndrome and alcohol-related dementiaby Robin Boere on November 17, 2024
CONCLUSIONS: This study aimed to investigate the ability to judge social norms in KS and ARD in comparison to healthy subjects. The results show that compared to a control group, both KS and ARD patients performed worse in judging social norms. KS and ARD patients scored equally low on social norms identification. Overall, these findings can further help us understand the difficulties in social behavior as experienced by patients and care staff, since problems in accurately judging social norms...
- Relationship between alcohol consumption and cognitive impairment in the adult population over 60 years of age: A systematic reviewby Josep Deví-Bastida on October 29, 2024
INTRODUCTION: Alcohol is the most consumed substance in Western culture and its use is a causal factor in more than 200 diseases and disorders. Our objective was to determine the relationship between alcohol consumption and cognitive impairment in people aged ≥60, and identify which cognitive functions are most affected by prolonged alcohol consumption.