Intellectual Development Disorder
Wiki Number: W107
Diagnosis: Intellectual Development Disorder
US Patients: 2-3%
Causes: Mental Retardation and Autism Spectrum make up the greatest proportions
Medications: antipsychotics and benzodiazepines
Therapies: careful analysis and years of good teaching; educable = IQ of 50-75;
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national studyby James J Sun on January 24, 2022
CONCLUSIONS: Significant levels of multi-morbidity, polypharmacy and a lack of systemised approach to treatment and risk exist. Addressing these concerns is essential to reduce premature mortality.
- Roots of the Malformations of Cortical Development in the Cell Biology of Neural Progenitor Cellsby Chiara Ossola on January 24, 2022
The cerebral cortex is a structure that underlies various brain functions, including cognition and language. Mammalian cerebral cortex starts developing during the embryonic period with the neural progenitor cells generating neurons. Newborn neurons migrate along progenitors' radial processes from the site of their origin in the germinal zones to the cortical plate, where they mature and integrate in the forming circuitry. Cell biological features of neural progenitors, such as the location and...
- Hyperexcitability and Homeostasis in Fragile X Syndromeby Xiaopeng Liu on January 24, 2022
Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability, resulting from a mutation in the FMR1 gene and subsequent loss of its protein product FMRP. Despite this simple genetic origin, FXS is a phenotypically complex disorder with a range of physical and neurocognitive disruptions. While numerous molecular and cellular pathways are affected by FMRP loss, there is growing evidence that circuit hyperexcitability may be a common convergence point that can account...
- Autism spectrum disorder and personality disorders: Comorbidity and differential diagnosisby Camilla Rinaldi on January 24, 2022
CONCLUSION: ASD in high-functioning adults is associated with a distinct personality profile even if variability exists. Further studies are needed to explore the complex relationship between ASD and PD.