Hypoactive Sexual Desire Disorder

Hypoactive sexual desire disorder (HSDD), now known as female sexual interest/arousal disorder, is a sexual dysfunction that causes a lowered sex drive in women. Many women will pass off the symptoms of HSDD as the inevitable effects of aging or changes in their body.


Cluster Number:
Wiki Number: W099
Diagnosis: Hypoactive Sexual Desire Disorder
US Patients: 10%Women
World Patients:
Sex Ratio:
Age Onset:
Brain Area: in men, higher serotonin than testosterone, unbalanced;in women, mood disorders, low prolactin, relationship problems
Symptoms: lack of desire for sex or lack of sexual fantasies; if neither of a couple is distressed, this is not a problem.
Causes: in men, low testosterone or high prolactin(precursor to testosterone); no known basis for lifetime lack of interest in sex
Medications: for women: bremelnotide before menopause and flibanserin after menopause.
Therapies: Understanding the culture, some cultures emphasize sexual restraint; others, sexual expression.


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Visceral therapy in disorders of the female reproductive organs
    by Malgorzata Wojcik on June 29, 2022

    Dyspareunia is genital pain during sexual intercourse without constriction of the vulva or vagina. This is one of the most significant issues that lies at the border of gynaecology and sexology. Dyspareunia can be caused by endometriosis. Many women can also experience premenstrual syndrome, which can occur as a separate problem. All three of these can result from an imbalance between the female genital organs and their surrounding tissues with other structures of the skeletal or visceral...

  • Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach
    by Chandrasekar Palanichamy on June 24, 2022

    Plants and their derived molecules have been traditionally used to manage numerous pathological complications, including male erectile dysfunction (ED). Mimosa pudica Linn. commonly referred to as the touch-me-not plant, and its extract are important sources of new lead molecules in drug discovery research. The main goal of this study was to predict highly effective molecules from M. pudica Linn. for reaching and maintaining penile erection before and during sexual intercourse through in silico...

  • Prevalence and Correlates of Sexual Aversion: A Canadian Community-Based Study
    by David Lafortune on June 24, 2022

    CONCLUSION: SA research is critical to document its prevalence in different sociodemographic groups, explore additional intrapersonal and interpersonal mechanisms involved in SA etiology, and ensure that the needs of people living with SA are met with tailored interventions. David Lafortune, √Čliane Dussault, Mathieu Philibert, Natacha Godbout. Prevalence and Correlates of Sexual Aversion: A Canadian Community-Based Study. J Sex Med 2022;XX:XXX-XXX.

  • Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial
    by Riccardo Pofi on June 15, 2022

    Cyclic GMP-phosphodiesterase type 5 (PDE5) inhibition has been shown to counteract maladaptive cardiac changes triggered by diabetes in some but not all studies. We performed a single-center, 20-week, double-blind, randomized, placebo-controlled trial (NCT01803828) to assess sex differences in cardiac remodeling after PDE5 inhibition in patients with diabetic cardiomyopathy. A total of 122 men and women (45 to 80 years) with long-duration (>3 years) and well-controlled type 2 diabetes mellitus...