Hypoactive Sexual Desire Disorder

Hypoactive sexual desire disorder (HSDD), now known as female sexual interest/arousal disorder, is a sexual dysfunction that causes a lowered sex drive in women. Many women will pass off the symptoms of HSDD as the inevitable effects of aging or changes in their body.


Cluster Number:
Wiki Number: W099
Diagnosis: Hypoactive Sexual Desire Disorder
US Patients: 10%Women
World Patients:
Sex Ratio:
Age Onset:
Brain Area: in men, higher serotonin than testosterone, unbalanced;in women, mood disorders, low prolactin, relationship problems
Symptoms: lack of desire for sex or lack of sexual fantasies; if neither of a couple is distressed, this is not a problem.
Causes: in men, low testosterone or high prolactin(precursor to testosterone); no known basis for lifetime lack of interest in sex
Medications: for women: bremelnotide before menopause and flibanserin after menopause.
Therapies: Understanding the culture, some cultures emphasize sexual restraint; others, sexual expression.

Youtube Video: Management of Hypoactive Sexual Desire Among Women

Youtube Video: Male Hypoactive Sexual Disorder

Amazon or Library Book:
Understanding Hypoactive Sexual Desire Disorder

Click the book to link or order from Amazon.


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Changes to hypothalamic volume and associated subunits during gender-affirming hormone therapy
    by Melisande E Konadu on September 26, 2023

    CONCLUSION: Our results suggest a subunit-specific effect of GHT on hypothalamus volumes in TW. This finding is in accordance with previous reports of positive and negative effects of androgens and estrogens, respectively, on cerebral volumes.

  • Sexual health and contraception in the menopause journey
    by Laura Cucinella on September 25, 2023

    Women may experience changes in sexuality across menopause, because at this step in life hormone deficiency interacts with several determinants in a bio-psycho-social perspective. Healthcare providers should inform women about menopause impact on sexuality and be proactive during consultation in disclosing sexual concerns that would require a targeted assessment. Sexual symptoms become more frequent as women age, but they do not always translate into sexual dysfunction diagnosis, for which...

  • Autophagy, a critical element in the aging male reproductive disorders and prostate cancer: a therapeutic point of view
    by Pourya Raee on September 25, 2023

    Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely...

  • The nature of co-morbid psychopathology in adolescents with gender dysphoria
    by M Karvonen on September 21, 2023

    Gender-referred adolescents (GR) have been reported to present with considerable psychiatric symptomatology compared to their age-peers. There is, however, little research on how they compare to adolescents referred due to mental health problems (MHR). We set out to compare psychopathology in adolescents referred to our specialized gender identity unit (n = 84) and adolescents referred to a general adolescent psychiatric clinic (n = 293) in a university hospital setting in Finland. Of the GR...