Abnormally increased and sometimes uncontrollable activity or muscular movements. 2 : a condition especially of childhood characterized by hyperactivity
Wiki Number: W097
Brain Area: The subthalamic nucleus improperly controls the basal ganglia producing these involuntary, unwanted movements.
Symptoms: several variations of excessive, unwanted muscle movements: ataxia, athetosis, chorea, dystonias, hemiballismus,
Progression: hemifacial spasms, myoclonus, stereotypies, tremors, tics, and volitional hyperkinesia; all are subsets of movements
Causes: Oversensitivity of dopamine and norepinephrine receptors or hyperactivity of the dopaminergic receptors appear.
Medications: Vary by diagnosis.
Therapies: Vary by diagnosis.
4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Case-report of neuroacanthocytosis associated with a compound mutation in the VPS13A geneby N A Skripkina on October 25, 2021
Neuroacanthocytosis is a group of neurodegenerative diseases manifested by a combition of neurological symptoms (most often choreic hyperkinesis) and the presence of an increased number of acanthocytes (erythrocytes with horns) in the peripheral blood. This group includes chorea-acanthocytosis, MacLeod's syndrome, pantothenate kinase-associated neurodegeneration, Huntington-like disease type 2, and some other very rare diseases. This article presents a genetically confirmed clinical case of...
- Hyperkinetic stereotyped movements in a boy with biallelic CNTNAP2 variantsby Marcello Scala on October 13, 2021
CONCLUSION: This case expands the molecular and phenotypic spectrum of CASPR2 deficiency disorder, suggesting that Hyperkinetic stereotyped movements may be a rare, yet significant, clinical feature of this complex neurological disorder. Furthermore, the identification of an in-frame, largely non-coding duplication in CNTNAP2 points to a sophisticated underlying molecular mechanism, likely involving impaired FOXP2 binding.
- Reply to: Subthalamic Nucleus Deep Brain Stimulation as Rescue Therapy for Levodopa Carbidopa Intestinal Gel-Associated Biphasic-Like Dyskinesiasby Eoin Mulroy on October 11, 2021
- Case Report: Takotsubo Cardiomyopathy After Traumatic Brain Injuryby Fajun Wang on October 4, 2021
Introduction: Takotsubo cardiomyopathy (TCM) or "stress cardiomyopathy" is an uncommon condition characterized by transient cardiac dysfunction with left ventricular apical ballooning in an appropriate clinical context. TCM has been observed in a variety of acute neurological conditions most prominently in patients with aneurysmal subarachnoid hemorrhage and status epilepticus. TCM has only been reported infrequently in association with traumatic brain injury (TBI). Herein we present a patient...