Disruptive Mood Dysregulation Disorder
Disruptive mood dysregulation disorder (DMDD) is a childhood condition of extreme irritability, anger, and frequent, intense temper outbursts. DMDD symptoms go beyond a being a “moody” child—children with DMDD experience severe impairment that requires clinical attention.
Wiki Number: W066
Diagnosis: Disruptive Mood Dysregulation Disorder
US Patients: 1.5% children
Age Onset: Child or adolescent
Brain Area: under-activity of the amygdala at judging other’s anger or sadness; medial front gyrus and anterior cingulate cortex – lower
Symptoms: disproportionate irritable or angry moods or several temper outbursts weekly; poor stress regulation; one year or more
Progression: displays persistent anger against people and objects, often have anxiety and depression in later years
Causes: Brain areas above are important for evaluating and regulating negative emotions; poverty and single-parenthood affect it
Medications: antidepressants, antipsychotics and mood stabilizers
Therapies: None listed.
4 CURRENT ARTICLES
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- Systematic Review and Meta-analysis: Pharmacological and Non-Pharmacological Interventions for Persistent Non-episodic Irritabilityby Rosanna Breaux on June 17, 2022
CONCLUSION: This meta-analysis provides a comprehensive review of interventions targeting persistent non-episodic irritability among youth with various psychiatric disorders. Strong evidence was found for medium-to-large effects across study design, intervention type, and clinical populations, with the largest effects for pharmacological interventions, particularly antipsychotic medications and combined pharmacological interventions, and interventions for youth with ASD.
- The Actin Cytoskeleton Responds to Inflammatory Cues and Alters Macrophage Activationby Elsa Ronzier on June 10, 2022
Much remains to be learned about the molecular mechanisms underlying a class of human disorders called actinopathies. These genetic disorders are characterized by loss-of-function mutations in actin-associated proteins that affect immune cells, leading to human immunopathology. However, much remains to be learned about how cytoskeletal dysregulation promotes immunological dysfunction. The current study reveals that the macrophage actin cytoskeleton responds to LPS/IFNγ stimulation in a biphasic...
- Structural Equation Modeling (SEM): Gaming Disorder Leading Untreated Attention-Deficit/Hyperactivity Disorder to Disruptive Mood Dysregulationby Ruu-Fen Tzang on June 10, 2022
(1) Background: Internet gaming disorder (IGD) in youths likely leads to disruptive mood dysregulation, especially among those with attention-deficit/hyperactivity disorder (ADHD). Whether IGD mediates the pathways leading ADHD to disruptive emotional dysfunction remains unclear. This study aims to elucidate the direct or indirect influence of IGD on ADHD; (2) Method: The Swanson, Nolan, and Pelham Version IV questionnaire was used to evaluate symptoms of ADHD and oppositional defiant disorder,...
- Synergistic Interaction of Low Salinity Stress With Vibrio Infection Causes Mass Mortalities in the Oyster by Inducing Host Microflora Imbalance and Immune Dysregulationby Xin Li on June 6, 2022
A sudden drop in salinity following extreme precipitation events usually causes mass mortality of oysters exposed to pathogens in ocean environment. While how low salinity stress interacts with pathogens to cause mass mortality remains obscure. In this study, we performed an experiment by low salinity stress and pathogen infection with Vibrio alginolyticus to investigate their synergistic effect on the mortality of the Pacific oyster toward understanding of the interaction among environment,...