Disruptive Mood Dysregulation Disorder
Disruptive mood dysregulation disorder (DMDD) is a childhood condition of extreme irritability, anger, and frequent, intense temper outbursts. DMDD symptoms go beyond a being a “moody” child—children with DMDD experience severe impairment that requires clinical attention.
Cluster Number:
Wiki Number: W066
Diagnosis: Disruptive Mood Dysregulation Disorder
US Patients: 1.5% children
World Patients:
Sex Ratio:
Age Onset: Child or adolescent
Brain Area: under-activity of the amygdala at judging other’s anger or sadness; medial front gyrus and anterior cingulate cortex – lower
Symptoms: disproportionate irritable or angry moods or several temper outbursts weekly; poor stress regulation; one year or more
Progression: displays persistent anger against people and objects, often have anxiety and depression in later years
Causes: Brain areas above are important for evaluating and regulating negative emotions; poverty and single-parenthood affect it
Medications: antidepressants, antipsychotics and mood stabilizers
Therapies: None listed.
Youtube Video: Treatment Challenges of Impulse Control
Behavioral Disorder
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4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Irritability, Negative Life Events and the Course of Anxiety and Depressive Symptoms in a Clinical Sample of Youth: A Longitudinal Studyby Camille Archer on May 3, 2024
CONCLUSION: Our findings suggest that, particularly in non-referred samples, NLE might moderate the relationship between irritability and future anxiety such that irritability/ anger in the context of NLE can positively affect the course of anxiety. Future work replicating this finding while repeatedly measuring NLE and rigorously controlling for potentially confounding effects of treatment, is warranted.
- Genetic and inflammatory factors underlying gestational diabetes mellitus: a reviewby Gyan Watson Ray on May 2, 2024
Gestational diabetes mellitus (GDM) poses a significant global health concern, impacting both maternal and fetal well-being. Early detection and treatment are imperative to mitigate adverse outcomes during pregnancy. This review delves into the pivotal role of insulin function and the influence of genetic variants, including SLC30A8, CDKAL1, TCF7L2, IRS1, and GCK, in GDM development. These genetic variations affect beta-cell function and insulin activity in crucial tissues, such as muscle,...
- Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitroby Eleftheria Maria Panagiotou on April 30, 2024
Phthalates are found in everyday items like plastics and personal care products. There is an increasing concern that continuous exposure can adversely affect female fertility. However, experimental data are lacking to establish causal links between exposure and disease in humans. To address this gap, we tested the effects of a common phthalate metabolite, mono-(2-ethylhexyl) phthalate (MEHP), on adult human ovaries in vitro using an epidemiologically determined human-relevant concentration range...
- Systematic Review and Meta-Analysis: Pharmacological and Nonpharmacological Interventions for Disruptive Mood Dysregulation Disorderby Yuhan Zhang on April 29, 2024
Objectives: Disruptive mood dysregulation disorder (DMDD) is a relatively new diagnosis that comprises severe, nonepisodic irritability and recurrent outbursts of emotional instability in adolescents. This meta-analysis examined the efficacy of the available pharmacological and nonpharmacological interventions for DMDD. Methods: Literature searches were conducted in July 2023. To determine relevant articles, 330 abstracts were reviewed, and 39 articles were identified for full review. A...