Depression
A mental health disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.
Possible causes include a combination of biological, psychological, and social sources of distress. Increasingly, research suggests these factors may cause changes in brain function, including altered activity of certain neural circuits in the brain.
The persistent feeling of sadness or loss of interest that characterizes major depression can lead to a range of behavioral and physical symptoms. These may include changes in sleep, appetite, energy level, concentration, daily behavior, or self-esteem. Depression can also be associated with thoughts of suicide.
The mainstay of treatment is usually medication, talk therapy, or a combination of the two. Increasingly, research suggests these treatments may normalize brain changes associated with depression.
Cluster Number:
Wiki Number: W058
Diagnoses: Depression
US Patients:
World Patients: 300Mil; 4.4%
Sex Ratio: M;W+
Age Onset:
Brain Area:
Symptoms: low mood and aversion to activity; loss of pleasure;
Effects: the leading cause of disability world-wide;
Causes: childhood adversity ,unequal treatment of siblings, abuse; adult work-or-family stress, medical diagnosis, unemployment
Medications: antidepressants should not be used with initial encounters; long-term depression can benefit from medical help
Therapies: exercise, fond memories; self-help books;
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4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Prevalent, Incident, and Persistent Insomnia in a Population-Based Cohort Tested Before (2018) and During the First-Wave of COVID-19 Pandemic (2020)by Charles M Morin on October 26, 2021
CONCLUSIONS: The COVID-19 pandemic is associated with significant increases in insomnia and psychological symptoms compared to the pre-pandemic period. Large scale public sleep and mental health intervention programs should be prioritized during and after a pandemic such as the the COVID-19.
- Norbuprenorphine Interferences in Urine Drug Testing LC-MS/MS Confirmation Methods From Quetiapine Metabolitesby Ana Celia Muñoz-Muñoz on October 26, 2021
Norbuprenorphine interferences were observed in urine drug testing LC-MS/MS confirmation methods used to assess patient compliance with prescribed buprenorphine for chronic pain and opioid use disorder. The interferences were observed in the norbuprenorphine MS/MS transitions, m/z 414.4/83.1 and 414.4/187.2, at and near the norbuprenorphine retention time at multiple laboratories using different sample preparation procedures and chromatographic conditions. When the interferences were present, a...
- Factors Associated with Resilience Among Older People Living with HIVby Jeff Berko on October 26, 2021
Resilience, a measure of stress coping ability, may be important in helping older people (age 50+) living with HIV (PLWH) age successfully, but limited data exist regarding factors that contribute to resilience for this group. This study uses the Connor-Davidson Resilience Scale 2 (CD-RISC2) to assess resilience, based on a cross-sectional analysis of 1047 older PLWH. Bivariate linear regression models were used to identify predictor variables that had a relationship with resilience. Those...
- Long-term consequences of COVID-19 on cognitive functioning up to 6 months after discharge: role of depression and impact on quality of lifeby Sara Poletti on October 26, 2021
Neurologic and psychiatric symptoms have been reported in the months following the infection with COVID-19. A low-grade inflammation has been associated both with depression and cognitive symptoms, suggesting a link between these disorders. The aim of the study is to investigate cognitive functioning 6 months following hospital discharge for COVID-19, the impact of depression, and the consequences on quality of life. Ninety-two COVID-19 survivors evaluated at 1-month follow-up, 122 evaluated at...