Depersonalization Disorder

Depersonalization/derealization disorder is a type of dissociative disorder that consists of persistent or recurrent feelings of being detached (dissociated) from one’s body or mental processes, usually with a feeling of being an outside observer of one’s life (depersonalization), or of being detached from one’s surroundings (derealization). The disorder is often triggered by severe stress. Diagnosis is based on symptoms after other possible causes are ruled out. Treatment consists of psychotherapy plus drug therapy for any comorbid depression and/or anxiety.


Cluster Number:
Wiki Number: 57
Diagnosis: Depersonalization Disorder
US Patients: 20% with head injuries
World Patients:
Sex Ratio: M;W3
Age Onset:
Brain Area: more cortisol after stress; neurological diseases of the brain;
Symptoms: feel like an observer of the self; the “self” seems to be someone else;
Progression: coping mechanism for high stress or PTSD;
Causes: trauma; withdrawal from recreational drugs; benzodiazepine dependence;
Medications: naloxone


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Acute Psychosis Following Corticosteroid Administration
    by Sana Elham Kazi on October 25, 2021

    Glucocorticoids are commonly used to treat endocrine as well as non-endocrine disorders. Unfortunately, these agents are associated with multiple adverse effects affecting various organ systems. A 55-year-old woman with type 2 diabetes mellitus and hypertension with no past psychiatric history was admitted to the hospital for acute hypoxic respiratory failure secondary to coronavirus disease 2019 (COVID-19) pneumonia. The patient did not exhibit any psychiatric symptoms during the initial...

  • Burnout and resilience among pharmacy technicians: A Singapore study
    by Jin Jian Chong on October 24, 2021

    CONCLUSION: Burnout affects most PTs in Singapore and is primarily driven by workload and nature of their work, low resilience, and poor social support structures. National and organizational efforts are needed to arrest the vicious cycle that propagates burnout in PTs.

  • Mindfulness-Based Interventions to Reduce Burnout in Primary Healthcare Professionals: A Systematic Review and Meta-Analysis
    by Mafalda Salvado on October 23, 2021

    Mindfulness-based interventions (MBIs) are reported by experimental studies as practical approaches to reduce burnout in primary healthcare professionals (PHCP). However, to date, no research has synthesized the evidence to determine the overall effects of MBIs for reducing burnout in PHCP. We conducted a systematic review and meta-analysis to analyze the effects of MBIs to reduce burnout in PHCP. We searched articles in the PubMed/MEDLINE, Web of Science, Cochrane, and Scopus databases from...

  • A Network Analysis to Identify Associations between PTSD and Dissociation among Teenagers
    by Etzel Cardeña on October 22, 2021

    We conducted a network analysis of measures of dissociation and posttraumatic symptoms (PTS) with a varied sample of adolescents (N = 312), some of them previously exposed to war scenarios. The global measure of dissociation (A-DES) was uniquely linked to the arousal PTS symptom cluster (CRIES-13), in particular sleep problems, but not to the reexperiencing and avoidance clusters. Three of four (i.e., depersonalization/derealization, amnesia, mental partition/compartmentalization) dissociation...