Dementia
Dementia is a collective term used to describe various symptoms of cognitive decline, such as forgetfulness. It is a symptom of several underlying diseases and brain disorders. Dementia is not a single disease in itself, but a general term to describe symptoms of impairment in memory, communication, and thinking.
Cluster Number:
Wiki Number: W055
Diagnosis: Dementia
US Patients:
World Patients: 50 Mil
Sex Ratio:
Age Onset: Age 80+- 50%
Brain Area: hippocampus shrinks; temporal and parietal lobes shrink; the brain degenerates; SPECT & PET show vascular cause.
Symptoms: early signs: handling finances, getting lost, repeating things;later-need help eating, dressing, getting out of bed
Progression: Alzheimer’s=80%; vascular, 20%=blood loss to the brain; Lewy bodies=hallucinations; frontotemporal=language problems
Causes: lewy bodies, frontotemporal dementia;people with dementia average five other chronic diseases; 50% persistent pain
Medications: donepezil, antipsychotics; no medications show a preventative effect
Therapies: exercise helps sustain activities of daily living;music; diets with low saturated fat and good carbohydrates; vitamin D
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Sexual expression involving people with dementia living in long-term care facilities: staff's reactionsby Maria Isabel Fonseca on May 18, 2022
This study aims to explore and compare the reaction of long-term care staff towards situations of sexual intercourse in which one or both partners have dementia. Participants were 538 staff members at 28 Portuguese long-term care facilities. Data were collected using a printed questionnaire with seven vignettes with situations related to the sexuality of LTCF residents. In this study, three of these vignettes were analysed with situations in which residents were having relationships in their...
- Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementiaby Judith A Boel on May 18, 2022
CONCLUSION: MMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD-MCI.
- CKD Biomarkers, Cognitive Impairment, and Incident Dementia in an Older Healthy Cohortby Anne M Murray on May 18, 2022
CONCLUSION: Mild albuminuria was associated with worse baseline cognitive function, cognitive decline, and increased risk for incident CIND and dementia. Screening global cognitive tests for older persons with UACR ≥3 mg/mmol could identify those at elevated risk of cognitive decline and dementia.
- Molecular recognition of the interaction between ApoE and the TREM2 proteinby Zhenhua Mai on May 18, 2022
Alzheimer's disease (AD) is the most common type of dementia. The ε4 allele of the apolipoprotein E (ApoE) gene is the strongest known genetic risk factor for late-onset AD. Triggering receptor expressed on myeloid cells 2 (TREM2) is another important risk factor affecting the AD process after ApoE. Emerging evidence has identified TREM2 as a putative receptor for ApoE, raising the possibility that interactions between ApoE and TREM2 modulate the pathogenesis of AD. In this study, we performed...