Dementia
Dementia is a collective term used to describe various symptoms of cognitive decline, such as forgetfulness. It is a symptom of several underlying diseases and brain disorders. Dementia is not a single disease in itself, but a general term to describe symptoms of impairment in memory, communication, and thinking.
Cluster Number:
Wiki Number: W055
Diagnosis: Dementia
US Patients:
World Patients: 50 Mil
Sex Ratio:
Age Onset: Age 80+- 50%
Brain Area: hippocampus shrinks; temporal and parietal lobes shrink; the brain degenerates; SPECT & PET show vascular cause.
Symptoms: early signs: handling finances, getting lost, repeating things;later-need help eating, dressing, getting out of bed
Progression: Alzheimer’s=80%; vascular, 20%=blood loss to the brain; Lewy bodies=hallucinations; frontotemporal=language problems
Causes: lewy bodies, frontotemporal dementia;people with dementia average five other chronic diseases; 50% persistent pain
Medications: donepezil, antipsychotics; no medications show a preventative effect
Therapies: exercise helps sustain activities of daily living;music; diets with low saturated fat and good carbohydrates; vitamin D
Youtube Video: Living with
Young-Onset Dementia
Youtube Video: Later Stage Dementia: Brad and Jean’s Story
Book from Amazon or Library: 2022 Dementia Overview
Click the book to link or order from Amazon.
Support Groups: alz.org; This website allows searching for
local associations. (Alzheimer’s Association)
Contact your local Social Security Office for possible Disability benefits through their Disability Determination Service,
Section 12.02.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Virtual screening, ADMET prediction, molecular docking, and dynamic simulation studies of natural products as BACE1 inhibitors for the management of Alzheimer's diseaseby Davood Gheidari on November 3, 2024
Alzheimer's disease (AD) is a degenerative neurological disorder that chronically and irreversibly affects memory, cognitive function, learning ability, and organizational skills. Numerous studies have demonstrated BACE1 as a critical therapeutic target for AD, emphasizing the need for specific inhibition of BACE1 to develop effective therapeutics. However, current BACE1 inhibitors have certain limitations. Therefore, the aim of this study was to identify potential novel candidates derived from...
- Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analysesby Elisa Mantovani on November 3, 2024
Cognitive impairment (CI) is common in α-synucleinopathies, i.e., Parkinson's disease, Lewy bodies dementia, and multiple system atrophy. We summarize data from systematic reviews/meta-analyses on neuroimaging, neurophysiology, biofluid and genetic diagnostic/prognostic biomarkers of CI in α-synucleinopathies. Diagnostic biomarkers include atrophy/functional neuroimaging brain changes, abnormal cortical amyloid and tau deposition, and cerebrospinal fluid (CSF) Alzheimer's disease (AD)...
- Insights into young-onset dementia hospitalizations: An 8-year nationwide study using administrative databy Bárbara Ferraz Pinto on November 3, 2024
CONCLUSIONS: This study describes the complexity and strain of young-onset dementia hospitalizations providing a detailed overview and recommendations for further research and tailored interventions.
- Differences in Pharmacological Treatment of Heart Failure Among Persons with or without Major Cognitive Disorder: A Cross-Sectional Study Based on National Registries in Swedenby Linda Rankin on November 3, 2024
CONCLUSION: Our findings indicate that there is possible undertreatment among individuals with HF identified in specialized care with co-occurring major NCD. Major NCD was associated with less filled prescriptions of basal pharmacological treatments such as RAS inhibitors, BBs, and MRAs. Future research needs to not only investigate this relationship further but also focus on reasons for the undertreatment of HF and other comorbidities within this group.