Dementia is a collective term used to describe various symptoms of cognitive decline, such as forgetfulness. It is a symptom of several underlying diseases and brain disorders. Dementia is not a single disease in itself, but a general term to describe symptoms of impairment in memory, communication, and thinking.
Wiki Number: W055
World Patients: 50 Mil
Age Onset: Age 80+- 50%
Brain Area: hippocampus shrinks; temporal and parietal lobes shrink; the brain degenerates; SPECT & PET show vascular cause.
Symptoms: early signs: handling finances, getting lost, repeating things;later-need help eating, dressing, getting out of bed
Progression: Alzheimer’s=80%; vascular, 20%=blood loss to the brain; Lewy bodies=hallucinations; frontotemporal=language problems
Causes: lewy bodies, frontotemporal dementia;people with dementia average five other chronic diseases; 50% persistent pain
Medications: donepezil, antipsychotics; no medications show a preventative effect
Therapies: exercise helps sustain activities of daily living;music; diets with low saturated fat and good carbohydrates; vitamin D
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosisby Su Hyun Lee on October 26, 2021
The autophagy-lysosome pathway and apoptosis constitute vital determinants of cell fate and engage in a complex interplay in both physiological and pathological conditions. Central to this interplay is the archetypal autophagic cargo adaptor p62/SQSTM1/Sequestosome-1 which mediates both cell survival and endoplasmic reticulum stress-induced apoptosis via aggregation of ubiquitinated caspase-8. Here, we investigated the role of p62-mediated apoptosis in head and neck squamous cell carcinoma...
- Leukotriene Receptor Antagonist Use and Dementia Risk in Patients With Asthma: A Retrospective Cohort Studyby Yumi Ishikura on October 26, 2021
CONCLUSION: Our data suggest that the use of LTRAs may prevent the onset of dementia in asthmatic patients.
- Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infectionby Martina Patone on October 26, 2021
Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate hospital admissions from neurological complications in the 28 days after a first dose of ChAdOx1nCoV-19 (n = 20,417,752) or BNT162b2 (n = 12,134,782), and after a SARS-CoV-2-positive test (n = 2,005,280). There was an increased risk of Guillain-Barré syndrome...
- Case-control study of the association of chronic acid suppression and social determinants of health with COVID-19 infectionby Bing Zhang on October 26, 2021
Acid suppressants are widely-used classes of medications linked to increased risks of aerodigestive infections. Prior studies of these medications as potentially reversible risk factors for COVID-19 have been conflicting. We aimed to determine the impact of chronic acid suppression use on COVID-19 infection risk while simultaneously evaluating the influence of social determinants of health to validate known and discover novel risk factors. We assessed the association of chronic acid suppression...