Cocaine-use disorder (CUD) affects both structure and function of the brain. A triple network model of large-scale brain networks has been useful for identifying aberrant resting-state functional connectivity (rsFC) associated with mental health disorders including addiction. The present study investigated differences between people with CUD vs. controls (CONs) and whether putative differences were associated with drug-use outcomes. Participants with CUD (n = 38) and CONs (n = 34) completed a...

Cocaine inhalation - and its popular derivative known as crack cocaine - is linked to numerous complications and organ damage, well-recognized in scientific literature, including airway injuries. Airways damage is probably due both to thermal damage by hot vapor and micro-inhalation of crystals, leading to foreign body trauma and inflammation. A brief description of findings is helpful to health professionals - including forensic pathologist - to achieve the correct diagnosis. Our study is of a...

CONCLUSION: Patients with a reported history of cocaine use were primarily men, Black, and had a lower average age of TKA with significant preoperative comorbidities of obesity, schizophrenia, mood disorder, and anxiety disorder. Cocaine use was associated with extended hospital stays, more expensive charges, and postoperative complications of acute renal failure and periprosthetic infection after TKA. However, more research is needed concerning cocaine dosage, route of administration, and...

Prolonged cocaine inhalation can cause destruction of nasal mucosa and ethmoid sinuses and palate perforation, thus inducing cocaine-induced midline destructive lesions (CIMDL) that affect only a limited number of predisposed patients. CIMDL are an autoimmune necrotizing inflammatory phenomenon associated with the presence of atypical antineutrophil cytoplasmic antibody (ANCA). Patients complain of epistaxis, nasal obstruction, hyposmia, sinus infections, and facial pain. Protocol for the CIMDL...