Childhood Disintegrative Disorder

Childhood disintegrative disorder (CDD), also known as Heller’s syndrome and disintegrative psychosis, is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills.


Cluster Number:
Wiki Number: W039
Diagnosis: Childhood Disintegrative Disorder
US Patients:
World Patients:
Sex Ratio:
Age Onset: Ages3-4
Brain Area:
Symptoms: Child’s language, social, play, motor skills reverse, loses control over bowel and bladder. Interaction, communication lag.
Progression: Excess fats build in the brain and nervous system with benign tumors growing in the brain; myelin sheaths in brain lost.
Medications: Antipsychotics for behavior problems and anticonvulsants to reduce seizures.
Therapies: Applied Behavior Analysis-teaches adaptation. Sensor experiences enriched


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Childhood Disintegrative Disorder (CDD): Symptomatology of the Norwegian Patient Population and Parents' Experiences of Patient Regression
    by Martin John Ellis on May 2, 2021

    Childhood Disintegrative Disorder (CDD) is a rare and little researched developmental disorder characterised by regression in language and social skills after a period of seemingly normal development until at least the age of 2 years. The study contacted all parents of CDD patients in Norway to assess patient symptomatology and parents' experiences of regression via questionnaire or interview. There were 12 participants. Symptomatology was in-line with previous studies, with universal regression...

  • Clinical Relevance of Methylenetetrahydrofolate Reductase Genetic Testing in Autism: A Case Report of Successful Clinical Outcome
    by None Fadila on February 12, 2021

    Autism spectrum disorder is an emerging public health issue. The core features of autism spectrum disorder are persistent impairment in reciprocal social communication and interaction and restricted, repetitive patterns of behavior or interests. We now know that it encompasses disorders previously referred to as early infantile autism, childhood autism, Kanner autism, high-functioning autism, atypical autism, Asperger disorder, childhood disintegrative disorder, and pervasive developmental...

  • Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders
    by Yuan-Mei Wang on January 5, 2021

    Autism spectrum disorders (ASDs) are a group of complex neurodevelopmental disorders, including autistic disorder, Asperger's syndrome, pervasive developmental disorder and childhood disintegrative disorder. Mitochondria not only provide neurons with energy in the form of ATP to sustain neuron growth, proliferation and neurodevelopment, but also regulate neuron apoptosis, intracellular calcium ion (Ca^(2+)) homeostasis, and reactive oxygen species (ROS) clearance. Due to their postmitotic state...

  • Asperger Syndrome
    by Seyed Alireza Hosseini on January 1, 2021

    Asperger syndrome (AS) was first described by Hans Asperger in 1944, as the behavioral characterization of individuals who have difficulties in communication and social interaction. Since then, AS has always been a topic of significant interest and debate. Although AS was introduced as a discrete diagnostic category in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-4, 1994), almost 20 years later, its diagnostic label was removed in the Diagnostic and...