Childhood Disintegrative Disorder

Childhood disintegrative disorder (CDD), also known as Heller’s syndrome and disintegrative psychosis, is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills.


Cluster Number:
Wiki Number: W039
Diagnosis: Childhood Disintegrative Disorder
US Patients:
World Patients:
Sex Ratio:
Age Onset: Ages3-4
Brain Area:
Symptoms: Child’s language, social, play, motor skills reverse, loses control over bowel and bladder. Interaction, communication lag.
Progression: Excess fats build in the brain and nervous system with benign tumors growing in the brain; myelin sheaths in brain lost.
Medications: Antipsychotics for behavior problems and anticonvulsants to reduce seizures.
Therapies: Applied Behavior Analysis-teaches adaptation. Sensor experiences enriched

Youtube Video: Childhood Disintegrative Disorder

Amazon or Library Book:

When Autism Strikes-Families Cope With Childhood Disintegrative Disorder

(Published,1998; $101.11 – new; cheaper, used copies)

Click to link or order from Amazon.

Support Group: (child-autism-parents-section)


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Later onset of Childhood Disintegrative Disorder (CDD): a case report
    by Silvia Di Vara on November 12, 2022

    Childhood Disintegrative Disorder (CDD) is a rare condition characterized by regression of developmental and behavioral functioning after a period of apparently normal development, with an age of onset around 4 years. CDD is not included within the latest edition of the Diagnostic and Statistical Manual of Mental Disorders. We present a case report of an 11-year-old male who achieved normal development for up to 7 years followed by a deterioration of previously acquired linguistic, intellectual,...

  • The Characteristics and Results of Parent Training Interventions in Children with Autism Spectrum Disorder: A Systematic Review
    by Seyed Hasan Tabatabaei on July 22, 2022

    CONCLUSION: According to the included studies, parents-based training interventions significantly impact parents and their children's behavior.

  • Asperger Syndrome
    by Seyed Alireza Hosseini on January 1, 2022

    Asperger syndrome (AS) was first described by Hans Asperger in 1944, as the behavioral characterization of individuals who have difficulties in communication and social interaction. Since then, AS has always been a topic of significant interest and debate. Although AS was introduced as a discrete diagnostic category in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-4, 1994), almost 20 years later, its diagnostic label was removed in the Diagnostic and...

  • Autism Spectrum Disorder
    by Saba Mughal on January 1, 2022

    Autism spectrum disorder (ASD) encompasses a spectrum of neurodevelopmental disabilities. This spectrum is characterized by repetitive patterns of behavior, interests, activities, and problems in social interactions. ASD is a complicated neurodevelopmental disorder that is characterized by behavioral and psychological problems in children. These children become distressed when their surrounding environment is changed because their adaptive capabilities are minimal. The symptoms are present from...