Catalepsy (from Ancient Greek katálēpsis, κατάληψις, “seizing, grasping”) is a nervous condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain.
Wiki Number: W035
Symptoms: muscular rigidy and increased pain; slowing of bodily functions, such as breathing
Progression: Shakespeare used it in “Romeo and Juliet.” Other authors have described people thought to be dead instead.
Causes: varies: cocaine withdrawal, reaction to drugs to treat schizophrenia
Medications: None described.
Therapies: None described.
4 CURRENT ARTICLES
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- Characterization and Chemical Optimization of the D2 Dopamine Receptor-Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disordersby Ashley N Nilson on May 13, 2022
Schizophrenia is a devastating illness characterized by both positive (hallucinations, delusions) and negative (flat affect, decreased motivation) symptoms coupled with cognitive impairment. Current antipsychotic medications are effective in treating the positive symptoms through antagonism of the D2 dopamine receptor (D2R). However, antipsychotic treatment is also hindered by side-effects due to off-target activities at other GPCRs and unfavorable binding kinetics at the D2R. We have identified...
- Pharmacodynamics and Pharmacokinetics of the Non-Fentanyl Synthetic Opioid, Isotonitazene, in Male Ratsby Michael H Baumann on May 13, 2022
Illicitly manufactured fentanyl is fueling the current overdose epidemic, and non-fentanyl mu-opioid receptor (MOR) agonists are emerging in street drug markets worldwide. The etonitazene analog, isotonitazene, is one example of a non-fentanyl MOR agonist linked to overdose deaths. Little is known about the biological effects of isotonitazene in humans or animal models. To this end, we examined the pharmacodynamics, pharmacokinetics, and metabolism of isotonitazene in rats. Male rats were fitted...
- Parkinsonism Attenuation by Antihistamines via Downregulating the Oxidative Stress, Histamine, and Inflammationby Maira Ayaz on May 13, 2022
Parkinson disease (PD) is a neurodegenerative disorder of the motor activity of the brain, regulated by dopaminergic neurons of substantia nigra, resulting in an increased density of histaminergic fibers. This study was aimed to evaluate the effects of H1 antagonist's ebastine and levocetirizine in PD per se and in combination. Animals were divided into 9 groups (n = 10). Group 1 received carboxymethyl cellulose CMC (1 mL/kg). Group II was treated with haloperidol (1 mg/kg) (diseased group)....
- Midazolam Attenuates Esketamine-Induced Overactive Behaviors in Mice Before the Sedation, but Not During the Recoveryby Qinjun Chu on April 28, 2022
Esketamine showed more potency, more rapid recovery from anesthesia, and less psychotomimetic side effects when compared with ketamine. However, the patients still experience psychotomimetic side effects of esketamine. In order to investigate whether midazolam can attenuate the esketamine-induced overactive behaviors and neuronal hyperactivities, midazolam 0, 40, 80, and 120 mg/kg combined with esketamine 50 mg/kg were administrated on Kunming mice to assess the behaviors changes during...