Catalepsy
Catalepsy (from Ancient Greek katálēpsis, κατάληψις, “seizing, grasping”) is a nervous condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain.
Cluster Number:
Wiki Number: W035
Diagnosis: Catalepsy
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Symptoms: muscular rigidy and increased pain; slowing of bodily functions, such as breathing
Progression: Shakespeare used it in “Romeo and Juliet.” Other authors have described people thought to be dead instead.
Causes: varies: cocaine withdrawal, reaction to drugs to treat schizophrenia
Medications: None described.
Therapies: None described.
Amazon or Library Book: On the Curability of Certain Forms of Insanity, Epilepsy, Catalepsy, and Hysteria in Females
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4 CURRENT ARTICLES
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PubMed article’s summary-abstract.
- Synthesis and evaluation of novel ethyl ferulate derivatives as potent Keap1 inhibitors to activate the Nrf2/ARE pathway in Parkinson's diseaseby Amritha Chakkittukandiyil on November 27, 2024
The Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2/Antioxidant Response Elements (Keap1/Nrf2/ARE) pathway is essential for neuronal resilience against the complex pathogenesis of Parkinson's disease (PD). Activating this pathway by covalently modifying Keap1 cysteine residues is a promising strategy for regulating neuroprotective gene expression. Our study aimed to identify phytochemicals that could irreversibly inhibit Keap1. A preliminary docking analysis...
- Efficacy and safety of prophylactic use of benzhexol after risperidone treatment in MK-801-induced mouse model of schizophreniaby Yongjie Zhong on November 17, 2024
CONCLUSIONS: We found that the prophylactic use of benzhexol can reduce the occurrence of EPS and does not affect the efficacy of risperidone in the treatment of positive symptoms. Benzhexol may impair cognitive function but did not cause further deterioration of cognitive function in MK-801 mice.
- Molecular and Behavioral Neuroprotective Effects of Clavulanic Acid and Crocin in Haloperidol-Induced Tardive Dyskinesia in Ratsby Parisa Shoae-Hagh on November 9, 2024
Clavulanic acid (ClvA), a beta-lactamase inhibitor, is being explored for its significant neuroprotective potential. The effects of ClvA were assessed both individually and in combination with crocin (Cr), an antioxidant derived from saffron, in the context of tardive dyskinesia (TD). In rat haloperidol (Hp)-induced-TD (1 mg/kg, i.p. 21 days), the effects of ClvA (50, 100, 150 mg/kg) and Cr (10, 20, 40 mg/kg) were assessed via vacuous chewing movements (VCM) and tongue protrusion (TP). Striatal...
- Repeated balance exercise promotes cholinergic neuroprotection of the pedunculopontine nucleus in a progressive model of Parkinson's diseaseby Thassya F O Dos Santos on November 3, 2024
Vestibular rehabilitation (VR) is a therapeutic approach that minimizes the impacts of balance alterations by enhancing the central vestibular compensation mechanism. The present study investigates the effect of repeated balance exercises on the central vestibular compensation mechanism in a reserpine-induced progressive model of parkinsonism in aged rats. Male Wistar rats were assigned to three cohort experiments: Exp 1: repeated balance exercises (narrow beam test) - performed every 48 h...