Caffeine Withdrawal

Caffeine withdrawal can occur in anyone who regularly consumes caffeine and then abruptly discontinues its use. Common symptoms include headache, fatigue, low energy, irritability, anxiety, poor concentration, depressed mood and tremors, which can last anywhere from two to nine days.


Cluster Number:
Wiki Number:
Diagnosis: W032
US Patients: Caffeine (Withdrawal)
World Patients: 84% daily
Sex Ratio:
Age Onset:
Brain Area:
Symptoms: interrupts adenosine’s natural tiredness inside of the blood-brain barrier, stimulates dopamine
Progression: reduces fatigue and drowsiness; improves reaction time, concentration and motor coordination.
Causes: primary benefit 1 hour – 3-4 hours after drinking; limit 2 cups during pregnancy; 3 cups during breast-feeding
Medications: withdrawal may induce sleepiness, irritability, headache and fatigue
Therapies: reducing caffeine decreases anxiety, jitters, anxiety attacks, depression and suicide

Amazon or Library Book: Caffeine Blues

Click the book to link or order from Amazon.

Support Group: SAMHSA; 800-662-4647;

(U.S. Government, Substance Abuse &

Mental Health Services Administration)


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Caffeine Delays Ethanol-Induced Sedation in Drosophila
    by Sonia Tremblay on January 21, 2023

    Caffeine and ethanol are among the most widely available and commonly consumed psychoactive substances. Both interact with adenosine receptor-mediated signaling which regulates numerous neurological processes including sleep and waking behaviors. In mammals, caffeine is an adenosine receptor antagonist and thus acts as a stimulant. Conversely, ethanol is a sedative because it promotes GABAergic neurotransmission, inhibits glutamatergic neurotransmission, and increases the amount of adenosine in...

  • Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial
    by Yu-Shiuan Lin on January 18, 2023

    Acute caffeine intake has been found to increase working memory (WM)-related brain activity in healthy adults without improving behavioral performances. The impact of daily caffeine intake-a ritual shared by 80% of the population worldwide-and of its discontinuation on working memory and its neural correlates remained unknown. In this double-blind, randomized, crossover study, we examined working memory functions in 20 young healthy non-smokers (age: 26.4 ± 4.0 years; body mass index: 22.7 ± 1.4...

  • Reduction in caffeine withdrawal after open-label decaffeinated coffee
    by Llewellyn Mills on January 11, 2023

    CONCLUSION: It appears as if open-label placebo caffeine (i.e. decaf) can reduce caffeine withdrawal symptoms, even when people do not hold a conscious expectancy it will do so. There may be ways to integrate open-label placebo procedures into clinical interventions for drug dependence without violating informed consent.

  • Effects of chronic caffeine intake and withdrawal on neural activity assessed via resting-state functional magnetic resonance imaging in mice
    by Mitsuki Rikitake on November 28, 2022

    Caffeine is a psychoactive substance that not only improves wakefulness, but also slows the cognitive decline caused by aging. However, at present, there are no reports about the effects of caffeine withdrawal, including headaches and changes in brain functional networks (nerve activity). Headache may occur approximately 24 h after discontinuing caffeine intake in chronic caffeine drinkers. The current study aimed to examine the brain functional activity via resting-state functional magnetic...