Caffeine Dependence

Caffeine is a commonplace central nervous system stimulant drug which occurs in nature as part of the coffee, tea, yerba mate, cocoa and other plants. It is also an additive in many consumer products, most notably beverages advertised as energy drinks and colas.


Cluster Number:
Wiki Number: W031
Diagnosis: Caffeine Dependence
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Use increases dopamine and norepinephrine
Symptoms: Stimulates reward system, but not enough to hijack it like cocaine.
Progression: Stimulating adnosine receptors induces tiredness & need to sleep;
Causes: Effects of coffee lessen and tolerance increases because the body makes more adenosine receptors.
Medications: None listed.
Therapies: Reduction in coffee to decaffinated coffee or teas. Reduce children’s soft-drink consumption.


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Regulation of host factor γ-H2AX level and location by enterovirus A71 for viral replication
    by Jinghua Yu on January 24, 2022

    Numerous viruses manipulate host factors for viral production. We demonstrated that human enterovirus A71 (EVA71), a primary causative agent for hand, foot, and mouth disease (HFMD), increased the level of the DNA damage response (DDR) marker γ-H2AX. DDR is primarily mediated by the ataxia telangiectasia mutated (ATM), ATM and Rad3-related (ATR), or DNA-dependent protein kinase (DNA-PK) pathways. Upregulation of γ-H2AX by EVA71 was dependent on the ATR but not the ATM or DNA-PK pathway. As a...

  • Individual Radiosensitivity as a Risk Factor for the Radiation-Induced Acute Radiodermatitis
    by Juras Kišonas on January 21, 2022

    CONCLUSIONS: The additional skincare did not improve skin condition during RT. A total of 89% of patients had increased radiosensitivity. IRS determined before RT did not show the predictive value for the manifestation of ARD. Logistic regression revealed that breast volume was the most significant risk factor for the manifestation of ARD.

  • Disorders of the Cholinergic System in COVID-19 Era-A Review of the Latest Research
    by Marta Kopańska on January 21, 2022

    The appearance of the SARS-CoV-2 virus initiated many studies on the effects of the virus on the human body. So far, its negative influence on the functioning of many morphological and physiological units, including the nervous system, has been demonstrated. Consequently, research has been conducted on the changes that SARS-CoV-2 may cause in the cholinergic system. The aim of this study is to review the latest research from the years 2020/2021 regarding disorders in the cholinergic system...

  • A machine learning approach to predict e-cigarette use and dependence among Ontario youth
    by Jiamin Shi on January 19, 2022

    CONCLUSION: Machine learning is a promising methodology for identifying the risks of ever-vaping and daily vaping. Furthermore, it enables the identification of important correlates and the assessment of complex intersections, which may inform future longitudinal studies to customize public health policies for targeted population subgroups.