Caffeine Dependence

Caffeine is a commonplace central nervous system stimulant drug which occurs in nature as part of the coffee, tea, yerba mate, cocoa and other plants. It is also an additive in many consumer products, most notably beverages advertised as energy drinks and colas.


Cluster Number:
Wiki Number: W031
Diagnosis: Caffeine Dependence
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Use increases dopamine and norepinephrine
Symptoms: Stimulates reward system, but not enough to hijack it like cocaine.
Progression: Stimulating adnosine receptors induces tiredness & need to sleep;
Causes: Effects of coffee lessen and tolerance increases because the body makes more adenosine receptors.
Medications: None listed.
Therapies: Reduction in coffee to decaffinated coffee or teas. Reduce children’s soft-drink consumption.


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Cardiomyocyte Na+ and Ca2+ mishandling drives vicious cycle involving CaMKII, ROS, and ryanodine receptors
    by Bence Hegyi on October 14, 2021

    Cardiomyocyte Na^(+) and Ca^(2+) mishandling, upregulated Ca^(2+)/calmodulin-dependent kinase II (CaMKII), and increased reactive oxygen species (ROS) are characteristics of various heart diseases, including heart failure (HF), long QT (LQT) syndrome, and catecholaminergic polymorphic ventricular tachycardia (CPVT). These changes may form a vicious cycle of positive feedback to promote cardiac dysfunction and arrhythmias. In HF rabbit cardiomyocytes investigated in this study, the inhibition of...

  • Caffeine Improves GABA Transport in the Striatum of Spontaneously Hypertensive Rats (SHR)
    by Regina Célia Cussa Kubrusly on October 12, 2021

    The spontaneously hypertensive rat (SHR) is an excellent animal model that mimics the behavioral and neurochemical phenotype of attention-deficit/hyperactivity disorder (ADHD). Here, we characterized the striatal GABA transport of SHR and investigated whether caffeine, a non-selective antagonist of adenosine receptors, could influence GABAergic circuitry. For this purpose, ex vivo striatal slices of SHR and Wistar (control strain) on the 35th postnatal day were dissected and incubated with...

    by Hannah C Sheridan on October 8, 2021

    The physical demands of professional female football have intensified in recent years. Supplements are only advised in addition to a healthy, balanced diet, but may warrant a greater prevalence in the professional game to support well-being, recovery, and performance. Supplements used by players should be safe, legal, and scientifically proven to be effective. An individual approach should be taken to using supplements dependant on the needs and goals of the player. Female players should aim to...

  • Association of coffee, green tea, and caffeine with the risk of dementia in older Japanese people
    by Nana Matsushita on October 8, 2021

    CONCLUSIONS: High levels of coffee and caffeine consumption were significantly associated with a reduced dementia risk in a dose-dependent manner, especially in men. Moreover, coffee consumption of ≥3 cups/day was associated with a 50% reduction in dementia risk.