Caffeine Dependence
Caffeine is a commonplace central nervous system stimulant drug which occurs in nature as part of the coffee, tea, yerba mate, cocoa and other plants. It is also an additive in many consumer products, most notably beverages advertised as energy drinks and colas.
Cluster Number:
Wiki Number: W031
Diagnosis: Caffeine Dependence
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Use increases dopamine and norepinephrine
Symptoms: Stimulates reward system, but not enough to hijack it like cocaine.
Progression: Stimulating adnosine receptors induces tiredness & need to sleep;
Causes: Effects of coffee lessen and tolerance increases because the body makes more adenosine receptors.
Medications: None listed.
Therapies: Reduction in coffee to decaffinated coffee or teas. Reduce children’s soft-drink consumption.
Youtube Video: History of Coffee-Global Addiction
Amazon or Library Book: Caffeine Addiction Cure:
The Ultimate Guide to Overcome Caffeine Addiction
Click the book to link or order from Amazon.
Support Group: caffeineaddictsanonymous.com; ON-line;
(12-Step Program)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Regulation of SR and mitochondrial Ca2+ signaling by L-type Ca2+ channels and Na/Ca exchanger in hiPSC-CMsby Xiao-Hua Zhang on December 18, 2024
CONCLUSION: Spontaneous hiPSCCMs pacing is triggered by influx of calcium through L-type Ca^(2+) channel that gates the release of SR pools supplemented by NCX-mediated mitochondrial calcium contribution.
- Caffeine intake during gestation and lactation causes long-term behavioral impairments in heterogenic mice offspring in a sex-dependent mannerby Bruna da Silva Oliveira on December 16, 2024
Growing evidence has indicated a potential association between maternal consumption of caffeine and impaired cognition and behavior in rodent offspring. However, potential sex differences, as well as caffeine-related effects in subsequent generations are still poorly investigated. We aimed to investigate the impact of pre-and/or neonatal exposition to caffeine on the neurodevelopment of male and female mice offspring. Adult female Swiss mice were randomly divided into four experimental groups,...
- TLC densitometric approach for concurrent determination of quinary mixture for treatment of migraine with appraisal to method greenness and whitenessby Marco M Z Sharkawi on December 16, 2024
A new accurate, precise thin layer chromatographic (TLC densitometric) approach was developed for the simultaneous analysis of ergotamine tartrate (ERG), phenobarbital sodium (PHEN), caffeine anhydrous (CAF), dipyrone sodium (DIP) and meprobamate (MEP) in their pure form and in their combined formulation; (MIGRANIL tablets). TLC separation depended on using a stationary phase of TLC plates F(254) (20 × 10 cm) and using a developing system of ethyl acetate: methanol: n- hexane (8:2:3, by volume)...
- G-protein-coupled receptor 41 in cardiomyocytes: Effect of butyrate on intracellular Ca2+ and sarcomere shorteningby Youxiu Yao on December 9, 2024
G-protein-coupled receptor 41 (GPR41) is a Gα(i)-coupled receptor activated by short-chain fatty acids (SCFAs). Here, we tested that GPR41 is also expressed in cardiomyocytes and exerts a direct negative inotropic effect when activated by SCFA butyrate. Primary cardiomyocytes were isolated from wild-type (WT) and GPR41 knockout (GPR41^(-/-)) adult mice and intracellular Ca^(2+) concentration and cell shortening were measured using the IonOptix system. RNA localization (RNAScope), quantitative...