Effects of Fast-Track Surgery Care in Patients Undergoing Hepatobiliary Surgery and Its Impact on Clinical Indicators and Inflammatory Factors: A Randomised Controlled Trial

Scand J Caring Sci. 2025 Dec;39(4):e70109. doi: 10.1111/scs.70109.

ABSTRACT

OBJECTIVE: This paper analysed the effects of fast-track surgery (FTS) care on their clinical indicators and inflammatory factors in patients undergoing hepatobiliary surgery.

METHODS: Patients were divided into the FTS group (n = 65, applying FTS care) and control (CON) group (n = 65, applying routine care). In both groups, differences in postoperative clinical indicators, including the first times of getting out of bed, exhaust, defecation and feeding, and pain level were compared; 3-day postoperative serum levels of inflammatory factors, including C-reactive protein (CRP), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), were examined; 3-day postoperative levels of psychological stress, including the Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were evaluated; postoperative complications were recorded, and the quality of life was evaluated by the 36-item short form health survey (SF-36) at 1 month after discharge.

RESULTS: Postoperatively, the FTS group had shorter first times of getting out of bed, exhaust, defecation and feeding, and lower pain levels than the CON group. Serum CRP, TNF-α and IL-6 levels were lower in the FTS group than in the CON group. HAMA and HAMD scores were lower in the FTS group than in the CON group. The FTS group presented a lower total complication rate and higher SF-36 scores of each item at 1 month after discharge than the CON group (all p < 0.05).

CONCLUSION: FTS care applied to hepatobiliary surgery patients can accelerate the recovery of postoperative clinical indicators, reduce the level of inflammation and psychological stress in the body, present fewer postoperative complications and enhance the quality of life.

PMID:41041911 | DOI:10.1111/scs.70109