Novel Azepinoindoles as 5-HT2C Agonists for Treating Depression, Drug Addiction, Alcoholism, PTSD, and Neuropathic Pain

ACS Med Chem Lett. 2025 Jul 28;16(8):1507-1508. doi: 10.1021/acsmedchemlett.5c00426. eCollection 2025 Aug 14.

ABSTRACT

Provided herein are novel azepinoindoles as 5-HT2C agonists, pharmaceutical compositions, use of such compounds in treating depression, drug addiction, alcoholism, post-traumatic stress disorder (PTSD), and neuropathic pain, and processes for preparing such compounds.

PMID:40832530 | PMC:PMC12358981 | DOI:10.1021/acsmedchemlett.5c00426