Rafting toward a depression biomarker

Eur Arch Psychiatry Clin Neurosci. 2025 Aug 19. doi: 10.1007/s00406-025-02071-3. Online ahead of print.

ABSTRACT

The journey from the cytoskeleton and G protein signaling to a framework that might provide a simple blood diagnostic for depression as well as a harbinger of individual antidepressant response, has been convoluted, occasionally frustrating, but ultimately rewarding. Herein, I provide a travelogue of sorts on our progress toward this end, and also chart a course toward the goal of providing a simple, quantitative and objective, biomarker-driven assessment tool that reflects the neurobiology of depressed mood.

PMID:40828419 | DOI:10.1007/s00406-025-02071-3