World J Biol Psychiatry. 2025 Jul 14:1-10. doi: 10.1080/15622975.2025.2528231. Online ahead of print.
ABSTRACT
BACKGROUND: Emerging evidence suggests that neuroinflammation may contribute to suicidal behaviour by altering immune responses and neural-pathways. Polymorphisms in cytokine gene promoter regions have been previously associated with depression and suicidal behaviour. Psychological autopsy is a thorough investigation method to investigate suicide. To date, there is no reported association study linking psychological autopsy outcomes with inflammatory markers. This cross-sectional post-mortem study aimed to investigate the relationship between psychosocial behaviour and inflammatory genetic patterns.
MATERIAL AND METHODS: The Comprehensive Psychological Autopsy: Structured Interview Schedule was used to gather psychosocial data of suicide completers (n=234), and genotyping of polymorphic sites in the promoter regions of IL-1β, IL-4, IL-6, IL-10, and TNF-α genes was done.
RESULTS: Our study found a consistent correlation between risk genotypes of all the understudy SNPs with the negative social behaviours. In linear regression analysis, IL-6(-174G/C) demonstrated a protective effect across emotional and negative behavioural traits, whereas TNF-α(-308G/A) was associated with the general behaviour domain.
CONCLUSION: Although it cannot be generalised at this point, the findings of this study highlight a definite pattern of correlation between genetic-psychosocial and behavioural descriptions of suicide completers, also backed by linear regression models. The findings can be further tested rigorously to confirm worldwide.
PMID:40658598 | DOI:10.1080/15622975.2025.2528231
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