Accidental Ingestion of Extended-Release Guanfacine in a Toddler

Cureus. 2025 Jun 2;17(6):e85261. doi: 10.7759/cureus.85261. eCollection 2025 Jun.

ABSTRACT

This case report describes the clinical presentation and treatment following an exploratory ingestion of extended release (ER) guanfacine in a healthy toddler. Guanfacine, an alpha-2a agonist, can cause transient hypertension as it moves from the serum into the CNS where it causes the more commonly seen central nervous system (CNS) depression, hypotension, and bradycardia. Persistent hypertension requiring intravenous (IV) vasodilatory medication is a rare and life-threatening complication of an alpha-2 agonist with only one other published report. This case report re-emphasizes and further expands available literature on this rarely reported effect.

PMID:40612836 | PMC:PMC12225953 | DOI:10.7759/cureus.85261