Psychological impact of gestational trophoblastic disease: a cross-sectional study

Einstein (Sao Paulo). 2025 May 2;23:eAO1014. doi: 10.31744/einstein_journal/2025AO1014. eCollection 2025.

ABSTRACT

OBJECTIVE: To evaluate the psychological repercussions of gestational trophoblastic disease.

METHODS: A cross-sectional study including 100 women (50 with gestational trophoblastic disease and 50 without) was conducted between September 2020 and October 2021. Socio-demographic characteristics, quality of life, depression, and anxiety were evaluated and follow-up was performed at a referral center.

RESULTS: Women with gestational trophoblastic disease had a mean age and body mass index of 28.8±6.4 years and 24.7±5.0kg/m2, respectively; the corresponding values for the Control Group were 30.1±6.9 years (p=0.27) and 28.9±4.6kg/m2 (p<0.001). The Gestational Trophoblastic Disease Group presented a better general health status (p=0.04) than the Control Group. Among women with gestational trophoblastic disease, 62% and 46% had anxiety and depression, respectively; the corresponding percentages for women without gestational trophoblastic disease were 52% and 24% (p=0.64 and 0.08, respectively).

CONCLUSION: Multidisciplinary follow-up at a referral center may improve the mental health and quality of life scores of women with gestational trophoblastic disease.

PMID:40332179 | DOI:10.31744/einstein_journal/2025AO1014