The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder

Neuropsychiatr Dis Treat. 2025 Apr 13;21:867-873. doi: 10.2147/NDT.S509050. eCollection 2025.

ABSTRACT

BACKGROUND: Major depressive disorder (MDD) is significantly influenced by genetic factors. The present study aims to examine the potential correlation between the 4977 bp deletion of mitochondrial DNA (mtDNA) and MDD.

METHODS: The 4977 bp deletion of mtDNA was detected in the peripheral blood of 253 MDD patients and 257 healthy controls, with depression assessed by the Hamilton Depression Rating scale and functioning by the Global Assessment of Function Scale.

RESULTS: MDD patients had a higher incidence of the 4977 bp deletion, unaffected by demographic or clinical factors.

CONCLUSION: The 4977 bp deletion may be a trait marker for MDD.

PMID:40248810 | PMC:PMC12005199 | DOI:10.2147/NDT.S509050