Major Depressive Disorder
Cluster Number:
Wiki Number: PW115
Diagnosis: Major Depressive Disorder
US Patients:
World Patients: 163 Mil; 2% of world population
Sex Ratio: M;W2
Age Onset: 20s-30s; The average duration is 23 weeks, with three more during lifetime. ½ of patients will not have another episode.
Brain Area: 102 variations in the genome linked to depression; There is an extensive description of possible brain affects on depression.
Symptoms: Has at least two weeks of depressive mood; inability to enjoy pleasure; rumination; reduced sex drive, insomnia and hypersomnia
Progression: weight and appetite may be low; fatigue, social withdrawal, suicidal thoughts; delusions or sometimes hallucinations
Causes: 40%-hereditary; response to stressors, childhood abuse. The article claims general physicians miss 2/3 of depression diagnoses.
Medications: Antidepressants-for the deeply depressed; electroconvulsive therapy
Therapies: Counseling; transcranial magnetic stimulation, light therapy, exercise, light therapy,
Youtube Video: Major Depressive Disorder
Amazon or Library Book: Major Depressive Disorder
Click the book to link or order from Amazon.
Contact your local Social Security office for possible Disability Benefits through their Disability Determination Services,
Section 12.04.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosisÂ
Clicking each title opens the
PubMed article’s summary-abstract.
- Longitudinal associations between subjective cognitive impairment, pain and depressive symptoms in home-dwelling older adults: Modelling within-person effectsby Miharu Nakanishi on May 18, 2024
CONCLUSIONS: A directional relationship was observed from pain to depressive symptoms. Pain reduction holds a potential benefit in the prevention of depressive symptoms, ultimately optimising the QoL of older adults.
- Concurrent inflammation-related brain reorganization in multiple sclerosis and depressionby Lara S Molina Galindo on May 18, 2024
CONCLUSIONS: Similar structural network alterations in MDD and MS exist, suggesting possible common inflammatory events like demyelination, neuroinflammation that are caught by GWc analyses. These alterations may vary depending on the severity of symptoms and in the case of MS may elucidate the occurrence of comorbid depression.
- Effect of pharmacogenomic testing on the clinical treatment of patients with depressive disorder: A randomized clinical trialby Lei Xu on May 18, 2024
CONCLUSIONS: Pharmacogenomic testing-guided drug therapy can provide greater assistance in the treatment of depression.
- Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal modelsby Iulia Zoicas on May 18, 2024
Repetitive transcranial magnetic stimulation (rTMS) emerged as a non-invasive brain stimulation technique in the treatment of psychiatric disorders. Both preclinical and clinical studies as well as systematic reviews provide a heterogeneous picture, particularly concerning the stimulation protocols used in rTMS. Here, we present a review of rTMS effects in rodent models of depressive-like symptoms with the aim to identify the most relevant factors that lead to an increased therapeutic success....