Major Depressive Episode
Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Also called major depressive disorder or clinical depression, it affects how you feel, think and behave and can lead to a variety of emotional and physical problems. You may have trouble doing normal day-to-day activities, and sometimes you may feel as if life isn’t worth living.
More than just a bout of the blues, depression isn’t a weakness and you can’t simply “snap out” of it. Depression may require long-term treatment. But don’t get discouraged. Most people with depression feel better with medication, psychotherapy or both.
Cluster Number:
Wiki Number: PW116
Diagnosis: Major Depressive Episode
US Patients: If untreated can last for several months to two years. Symptoms may improve within 6-8 weeks with treatment.
World Patients:
Sex Ratio: M+;F
Age Onset: Ages 20-45
Brain Area:
Symptoms: Symptoms for two weeks of major depressive disorder: loss of interest or pleasure, anxiety, insomnia
Progression: saddened mood, poor sleep, loss of energy, concentration or appetite, thoughts of death or suicide
Causes: Neurotransmitters out of balance, feeling worthless and dispairing; heredity or familial causes
Medications: antidepressants which take 4-6 weeks until maximum effect;
Therapies: psychotherapy
Youtube Video: Major Depressive Episode Self-Care Strategies
Amazon or Library Book:
Handbook of Depression in Children and Adolescents
Click the book to link or buy from Amazon. (Very Expensive!)
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Support Group:adaa.org/supportgroups; Online
(Anxiety & Depression Association of America)
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disordersby Yanli Li on April 29, 2024
CONCLUSIONS: Patients with affective disorders had abnormal tryptophan metabolism, which involved in 5-HT and kynurenine pathway (KP) sub-pathway. Tryptophan metabolites might be potential biomarkers for affective disorders and some metabolites have been associated with remission of depressive symptoms.
- Altered functional brain activity in first-episode major depressive disorder treated with electro-acupuncture: A resting-state functional magnetic resonance imaging studyby XiaoLing Wang on April 29, 2024
CONCLUSION: EA demonstrates modulation of functional activity in the default mode network (DMN), sensorimotor network (SMN), cognitive control network (CCN), limbic system, and visual network (VN) for the treatment of the first-episode MDD. Our findings contribute to the neuroimaging evidence for the efficacy of EAS.
- The clinical perspective on late-onset depression in European real-world treatment settingsby Lucie Bartova on April 28, 2024
The clinical phenotype of the so-called late-onset depression (LOD) affecting up to 30% of older adults and yielding heterogeneous manifestations concerning symptoms, severity and course has not been fully elucidated yet. This European, cross-sectional, non-interventional, naturalistic multicenter study systematically investigated socio-demographic and clinical correlates of early-onset depression (EOD) and LOD (age of onset ≥ 50 years) in 1410 adult in- and outpatients of both sexes receiving...
- Higher Seasonal Variation of Systemic Inflammation in Bipolar Disorderby Sara Dallaspezia on April 27, 2024
Seasonal rhythms affect the immune system. Evidence supports the involvement of immuno-inflammatory mechanisms in bipolar disorder (BD), with the neutrophil to lymphocyte ratio (NLR), and the systemic immune-inflammatory index (SII; platelets × neutrophils/lymphocytes) consistently reported to be higher in patients with BD than in HC, but seasonal rhythms of innate and adaptive immunity have never been studied. We retrospectively studied NLR and SII in 824 participants divided into three groups:...