The misuse of pregabalin (Lyrica) has emerged as a common problem in recent years, particularly among vulnerable populations. This reality is reflected in the prison environment, where pregabalin is subject to abuse and trafficking. In this article, we detail the issues surrounding this misuse and our practical strategy for tackling it. It is based on four axes: a) clarification of the indication (or lack thereof); b) support of withdrawal with gabapentin; c) if applicable, management of the...

Pearl millet (PM) (Pennisetum glaucum L.) contains a wide variety of bioactive compounds, such as polyphenols, mostly flavonoids and phenolic acids. In the present study, we investigated the effects of PM activity against hydrogen peroxide (H(2)O(2))-induced behavior impairment and oxidative damage in rats. The rats were divided into four groups based on the treatments they received over 30 days: Control, H(2)O(2), PM + H(2)O(2), and PM. The phytochemical screening, total polyphenols content...

The advent of midazolam holds profound implications for modern clinical practice. The hypnotic and sedative effects of midazolam afford it broad clinical applicability. However, the specific mechanisms underlying the modulation of altered consciousness by midazolam remain elusive. Herein, using pharmacology, optogenetics, chemogenetics, fiber photometry, and gene knockdown, this in vivo research revealed the role of locus coeruleus (LC)-ventrolateral preoptic nucleus noradrenergic neural circuit...

Background: Dexmedetomidine (DEX) is a highly favored sedative agent in critically ill patients owing to its anxiolytic and analgesic properties, lower risk of delirium, and minimal respiratory depression. Additionally, DEX exhibits anti-inflammatory properties, which have prompted its use in managing COVID-19 patients to mitigate cytokine storm and multi-organ dysfunction. Thus, this study aims to evaluate the safety and effectiveness of DEX use in critically ill patients with COVID-19. Method:...