Alzheimer’s Disease
A progressive disease that destroys memory and other important mental functions.
Brain cell connections and the cells themselves degenerate and die, eventually destroying memory and other important mental functions.
Memory loss and confusion are the main symptoms.
No cure exists, but medications and management strategies may temporarily improve symptoms.
Cluster Number:
Wiki Number: W007
Diagnosis: Alzheimer’s Disease
US Patients:
World Patients: 30Mil
Sex Ratio: M; 3F
Age Onset: 65+to42% by 80+
Brain Area: hippocampus, amyloids & tau proteins, 19 genes
Symptoms: forgetting, poor short term memory, location confusion
Progression: poor thinking, repetitious conversations, abusive, anxious, paranoid, loses ability to live
Causes: 19 genes, head injuries, depression, hypertension, smoking
Medications: memantine, acetylcholinemesterase inhibitors
Therapies: Chess, book-reading, exercise;low-fat diet, caffeine, wine
Youtube Video: Alzheimer’s Disease-Early Signs
Amazon or Library Book:
Is It Alzheimer’s?
Amazon or Library Book:
36-Hour Day
Click the book to link or order from Amazon.
Click the book to link or order from Amazon.
Support Group: Alzheimer’s Association 800-272-3900
Contact your local Social Security office for possible Disability Benefits through their Disability Determination Services,
Section 12.02.
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- A Drosophila model for mechanistic investigation of tau protein spreadby Kondalarao Bankapalli on May 7, 2024
Brain protein aggregates are a hallmark of neurodegenerative disease. Previous work indicates that specific protein components of these aggregates are toxic, including tau in Alzheimer's disease and related tauopathies. Increasing evidence also indicates that these toxic proteins traffic between cells in a prion-like fashion, thereby spreading pathology from one brain region to another. However, the mechanisms involved in trafficking are poorly understood. We therefore developed a transgenic...
- Large-scale Deep Proteomic Analysis in Alzheimer's Disease Brain Regions Across Race and Ethnicityby Fatemeh Seifar on May 7, 2024
INTRODUCTION: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, yet our comprehension predominantly relies on studies within the non-Hispanic White (NHW) population. Here we aimed to provide comprehensive insights into the proteomic landscape of AD across diverse racial and ethnic groups.
- Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairmentby A Dutton on May 7, 2024
Neonatal herpes simplex virus (nHSV) is a devastating infection impacting approximately 14,000 newborns globally each year. Infection is associated with high neurologic morbidity and mortality, making early intervention and treatment critical. Clinical outcomes of symptomatic nHSV infections are well-studied, but little is known about the frequency of, or outcomes following, sub-clinical or asymptomatic nHSV. Given the ubiquitous nature of HSV infection and frequency of asymptomatic shedding in...
- A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging researchby Vikas Anil Gujjala on May 7, 2024
Since its first description in 1906 by Dr. Alois Alzheimer, Alzheimer's disease (AD) has been the most common type of dementia. Initially thought to be caused by age-associated accumulation of plaques, in recent years, research has increasingly associated AD with lysosomal storage and metabolic disorders, and the explanation of its pathogenesis has shifted from amyloid and tau accumulation to oxidative stress and impaired lipid and glucose metabolism aggravated by hypoxic conditions. However,...