Alcoholism
A chronic disease characterized by uncontrolled drinking and preoccupation with alcohol.
Alcoholism is the inability to control drinking due to both a physical and emotional dependence on alcohol.
Symptoms include a strong need or urge to use alcohol. Those with alcohol use disorder may have problems controlling their drinking, continue to use alcohol even when it causes problems, or have withdrawal symptoms when they rapidly decrease or stop drinking.
Treatment involves counseling, such as behavioral therapy, and medications that reduce the desire to drink. Some people need medical detoxification to stop drinking safely. Mutual support groups help people stop drinking, manage relapses and cope with necessary lifestyle changes.
Cluster Number:
Wiki Number: W0004
Diagnosis: Alcoholism
US Patients: 2016-5.1%
World Patients: 380Million
Sex Ratio: 2M-1F
Age Onset:
Brain Area:
Symptoms: Overstimulation of GABA receptors
Progression: increasing drinking
Causes: Cirrhosis of the liver, epilesy, cancer; dementia, women more likely
Medications: Acamprosate, naltrexone, opoids,
Therapies: Alcoholics Anonymous and 12-Step programs
Youtube Video: Warning Symptoms of Alcoholism
Amazon or Library Book:
Understanding Alcoholism as a Brain Disease
Click the book to link or order from Amazon.
Support Group: Alcoholics Anonymous-aa.org
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Modern pharmacotherapy guidance for treating alcohol use disordersby Michael Soyka on December 20, 2024
INTRODUCTION: Alcohol use disorder (AUD) is prevalent and recognized as a chronic, relapsing disorder. Even though effective treatment options are available, AUD is strongly undertreated. As adjuvant treatment strategies accompanying psychosocial treatments, pharmacological strategies can increase the efficacy of AUD treatment options.
- Growth hormone secretagogue receptor and cannabinoid receptor type 1 intersection in the mouse brainby Camila Saenz on December 20, 2024
The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, such as energy homeostasis, appetite control, reward, and stress responses. GHSR mediates the effects of both ghrelin and liver-expressed antimicrobial peptide 2, while CB1R is targeted by cannabinoids. Strikingly, both receptors mediate their effects by acting on common brain areas and their...
- Metabolic dysfunction-associated steatotic liver disease and gastroesophageal reflux disease: a mendelian randomization study in European and East Asian populationsby Chen'guang Su on December 20, 2024
CONCLUSION: There was reverse causality between MASLD and GERD in European population, while there was bidirectional causality between a proxie for MASLD (ALT) and GERD in East Asian population. This study can provide novel insights into cross-ethnic genetic research on MASLD and GERD.
- Burden of Hepatocellular Carcinoma and Its Underlying Etiologies in China, 1990-2021: Findings From the Global Burden of Disease Study 2021by Jiaye Long on December 20, 2024
CONCLUSIONS: In the past 30 years, although the overall incidence rate and mortality of HCC in China have declined, the proportion of HCCDAU and HCCDNASH has increased due to the increasingly serious problems of alcoholism and obesity. Therefore, interventions are needed to address the issues of alcohol consumption and obesity in order to control the incidence of HCCDAU and HCCDNASH.