Lewy body dementia
Resources for Patients and Caregivers
Lewy body dementia (LBD) is a disease associated with abnormal deposits of a protein called alpha-synuclein in the brain. These deposits, called Lewy bodies, affect chemicals in the brain whose changes, in turn, can lead to problems with thinking, movement, behavior, and mood.
Cluster Number:
Wiki Number: 26-Lewy Bodies Disorder/Dementia
Diagnosis:
US Patients: American actor and comedian Robin Williams committed suicide in 2014 with Parkinson’s and Lewy Bodies.
World Patients:
Sex Ratio:
Age Onset: after age 50 with life expectancy of 8 years after diagnosis
Brain Area: The SNCA gene encodes the alpha-synuclein protein which is a building-block of Lewy bodies.
Symptoms: acting out dreams, visual hallucinations, attention difficulties, slowness of movements
Progression: dementia and Parkinson’s patients may also be affected. Cause cognitive fluctuations.
Causes: clumps of protein form on brain neurons causing heart and digestive functions, low blood pressure and apathy.
Medications: several
Therapies: Cognitive training, deep-brain and transcranial direct current stimulations have been used.
Youtube Video: Lewy Body Disease
Amazon or Library Book:
A Caregiver’s Guide to Lewy Body Dementia
Click the book to link or buy from Amazon.
Support Group: lbda.org; 800-539-9767 (lewybodydementiaassociation)
Resources for Physicians, Counselors and Researchers
4 CURRENT ARTICLES
FROM PUBMED
The world-wide medical research
reports chosen for each diagnosis
Clicking each title opens the
PubMed article’s summary-abstract.
- Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson's disease and dementia with Lewy bodiesby Nandkishore R Belur on May 18, 2024
Neurodegenerative diseases are commonly classified as proteinopathies that are defined by the aggregation of a specific protein. Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are classified as synucleinopathies since α-synuclein (α-syn)-containing inclusions histopathologically define these diseases. Unbiased biochemical analysis of PD and DLB patient material unexpectedly revealed novel pathological inclusions in the nucleus comprising adenosine-to-inosine (A-to-I)-edited mRNAs...
- Parkinson's Disease Associated with G2019S LRRK2 Mutations without Lewy Body Pathologyby Lauren M Jackson on May 17, 2024
CONCLUSION: This case illustrates that levodopa-responsive clinical PD caused by G2019S LRRK2 mutations can occur without Lewy bodies.
- Association of Alzheimer's Disease and Other Neuropathologies with Functional Disability in Persons With and Without Dementiaby Jose M Farfel on May 17, 2024
CONCLUSION: AD and all other neuropathologies are strongly associated with functional disability. The association of most neuropathologies with disability was eliminated or attenuated by dementia, except for gross infarcts and microinfarcts.
- Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmineby Pankaj Kadyan on May 17, 2024
Neurodegenerative diseases (NDDs) encompass a range of conditions characterized by the specific dysfunction and continual decline of neurons, glial cells, and neural networks within the brain and spinal cord. The majority of NDDs exhibit similar underlying causes, including oxidative stress, neuroinflammation, and malfunctioning of mitochondria. Elevated levels of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), alongside decreased expression of brain-derived neurotrophic factor...