PLoS One. 2025 Aug 7;20(8):e0324365. doi: 10.1371/journal.pone.0324365. eCollection 2025.
ABSTRACT
BACKGROUND: Psychiatric disorders and chronic hepatitis virus C infection are known to alter blood cytokines levels. However, little is known about the association between cytokines and psychiatric symptoms in patients with chronic hepatitis C virus infection. This study aimed at exploring this association. Moreover, since nearly half of the patients receive opioid maintenance treatment, we also investigated if long-term opioid treatment had any impact on these associations.
METHODS: We conducted a cross-sectional study on 120 outpatients referred for antiviral hepatitis C treatment. Serum level of 27 cytokines was measured using multiplex technology, and psychiatric symptom clusters were assessed using the Symptoms Check-List-90-R. Data on confounding factors including age, gender, weight, height, current medication and smoking habits were collected. Multiple linear regression analysis was performed to examine associations, adjusting for confounding factors.
RESULTS: After adjusting for the most commonly known confounding factors, IP-10 and GM-CSF were negatively associated with depression, and GM-CSF was negatively associated with phobic anxiety. Subgroup analyses revealed that these associations were present only in patients receiving opioid maintenance treatment, as demonstrated by repeated regression analysis.
CONCLUSIONS: In patients with chronic hepatitis C viral infection, only IP-10 and GM-CSF were negatively associated with self-reported psychiatric symptom clusters. These associations were observed exclusively in patients receiving opioid maintenance treatment. Our study contributes to others investigations pointing to a possible immune dampening caused by long-term opioid treatment.
PMID:40773504 | DOI:10.1371/journal.pone.0324365
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