Alice In Wonderland Syndrome

Alice in Wonderland syndrome (AIWS) is a rare neurological disorder characterized by distortions of visual perception, the body image, and the experience of time. People may see things smaller than they are, feel their body alter in size or experience any of the syndrome’s numerous other symptoms.


Cluster Number:
Wiki Number: W006
Diagnosis: Alice In Wonderland Syndrome
US Patients:
World Patients:
Sex Ratio:
Age Onset: 6-done at 20
Brain Area: less blood in (temporal)side-lobes
Symptoms: Visual distortions from migraines, tumors, drug use
Progression: Own body or others seem larger/smaller//more near or far
Causes: Epstein-Barr Virus-“mono-nucleosis”,hereditary
Medications: topamirate, tyramine


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • On Perception and Consciousness in HPPD: A Systematic Review
    by Pieter J Vis on August 30, 2021

    Hallucinogen-persisting perception disorder (HPPD) features as a diagnostic category in the DSM-5, ICD-11, and other major classifications, but our knowledge of the phenomenology of the perceptual symptoms involved and the changes in consciousness during the characteristic "flashbacks" is limited. We systematically evaluated original case reports and case series on HPPD to define its phenomenology, associated (psycho)pathology, and course. Our search of PubMed and Embase yielded 66 relevant...

  • Life, death, genomics and psychiatry's struggle with esoteric disorders
    by Jan Dirk Blom on August 25, 2021

    No abstract

  • Jean-Martin Charcot (1825-1893) and the "Alice in Wonderland syndrome"
    by Francesco Brigo on August 11, 2021

    The "Alice in Wonderland syndrome" (AIWS) is a neurological disorder characterized by altered body schema perception, visual, or somesthetic symptoms, which is frequently associated with migraine. In this article, we present the earliest known description of symptoms attributable to AIWS in the medical literature. During a lecture held on November 22, 1887, at the Salpêtrière, Jean-Martin Charcot (1825-1893) examined a patient with somesthetic symptoms (partial macrosomatognosia) in the context...

  • Victor Parant (1848-1924) and the first report of psychosis in the course of Parkinson's disease with dementia
    by G Fénelon on July 12, 2021

    Until the beginning of the twentieth century, neurologists considered that mental disorders in the course of Parkinson's disease (PD) occurred in the terminal phases of the disease or were due to coincidental pathologies. Benjamin Ball (1834-1893), in 1881 and 1882, drew attention to the frequency of cognitive and depressive disorders in PD. In 1883, Victor Parant (1848-1924), referring to Ball's work, published the first detailed observation of a PD patient with dementia and psychotic symptoms....