Misophonia is a disorder in which certain sounds trigger emotional or physiological responses that some might perceive as unreasonable given the circumstance. Those who have misophonia might describe it as when a sound “drives you crazy.” Their reactions can range from anger and annoyance to panic and the need to flee.


Cluster Number:
Wiki Number: PW123
Diagnosis: Misophonia
US Patients:
World Patients:
Sex Ratio: B;G+
Age Onset: Ages 9-13
Brain Area:
Symptoms: sounds trigger unreasonable emotional or physiological responses; also called “selective sound sensitivity syndrome”
Progression: mouth-based sounds, eating, chewing, etc, are 80% of the sounds that bother people and 60% are repetitive
Causes: dysfunction fo the central auditory system in the brain; sufferers have more myelin around nerves
Therapies: coping strategies, tinnitus retraining therapy or CBT; There are online support groups identified in the Wikipedia article itself.


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • EMDR therapy for misophonia: a pilot study of case series
    by Inge Jager on September 30, 2021

    CONCLUSIONS: These preliminary results suggest that EMDR therapy focused on emotionally disturbing misophonia-related memories can reduce misophonia symptoms. RCTs with sufficient sample sizes are required to firmly establish the value of EMDR therapy for misophonia.

  • Family Experiences of Decreased Sound Tolerance in ASD
    by Nichole E Scheerer on September 15, 2021

    Decreased sound tolerance (DST) is the most common sensory difficulty experienced by autistic individuals. Parents of 88 autistic children and young adults between the ages of 3 and 30 described coping strategies and physical and emotional responses used to deal with distressing sounds, and their impact on daily activities. Loud, sudden, and high-pitched sounds were most commonly endorsed as distressing, most often causing autistic children and young adults to cover their ears or yell, while...

  • Explainable AI-based clinical decision support system for hearing disorders
    by Katarzyna A Tarnowska on August 30, 2021

    In clinical system design, human-computer interaction and explainability are important topics of research. Clinical systems need to provide users with not only results but also an account of their behaviors. In this research, we propose a knowledge-based clinical decision support system (CDSS) for the diagnosis and therapy of hearing disorders, such as tinnitus, hyperacusis, and misophonia. Our prototype eTRT system offers an explainable output that we expect to increase its trustworthiness and...

  • White matter abnormalities in misophonia
    by Nadine Eijsker on August 30, 2021

    Misophonia is a condition in which specific ordinary sounds provoke disproportionately strong negative affect and physiological arousal. Evidence for neurobiological abnormalities underlying misophonia is scarce. Since many psychiatric disorders show white matter (WM) abnormalities, we tested for both macro and micro-structural WM differences between misophonia patients and healthy controls. We collected T1-weighted and diffusion-weighted magnetic resonance images from 24 patients and 25 matched...