Diogenes Syndrome

Diogenes syndrome, also known as senile squalor syndrome, is a disorder characterized by extreme self-neglect, domestic squalor, social withdrawal, apathy, compulsive hoarding of garbage or animals, plus lack of shame. Sufferers may also display symptoms of catatonia.


Cluster Number:
Wiki Number: W062
Diagnosis: Diogenes Syndrome
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area: Pfc damage hurt decision-making; frontal lobe
Symptoms: hoarding of rubbish and severe self-neglect;
Progression: After hospitalization, 50% died, 25% placed in long-term-care;
Causes: later-life stresses may have caused physical collapse or nervous brakdown; 50% were successful and highly intelligent
Therapies: adult daycare facilities often help with the patient’s physical state and emotional isolation


The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Adipose-Derived Lipid-Binding Proteins: The Good, the Bad and the Metabolic Diseases
    by Laurie Frances on October 13, 2021

    Adipose tissue releases a large range of bioactive factors called adipokines, many of which are involved in inflammation, glucose homeostasis and lipid metabolism. Under pathological conditions such as obesity, most of the adipokines are upregulated and considered as deleterious, due to their pro-inflammatory, pro-atherosclerotic or pro-diabetic properties, while only a few are downregulated and would be designated as beneficial adipokines, thanks to their counteracting properties against the...

  • Diogenes syndrome in a 10-year retrospective observational study: An elderly case series in Tokyo
    by Kae Ito on October 3, 2021

    CONCLUSIONS: In the present study, social isolation, living alone, advanced dementia, and reduced BADL were found to be associated with DS. In addition, DS had a high risk of early death. Support for DS must take into account not only mental and social health, but also physical health from an early stage.

  • Lethal giant basal cell carcinoma
    by Roger W Byard on September 3, 2021

    Basal cell carcinomas are the most common malignancy in Caucasian populations with a very low predisposition to metastatic disease and an excellent prognosis if appropriately treated. Given the rarity of a lethal outcome two cases are reported. Case 1: A 61-year-old reclusive man who had an untreated facial basal cell carcinoma for 10 years died of hypothermia and sepsis complicating the extensively ulcerated and infected tumour. He also had underlying cardiomegaly, ischaemic heart disease and...

  • Heart Disease and the Kidneys
    by Ricardo Pereira Silva on August 24, 2021

    Clinical Background: The heart can cause kidney disease, and the kidney can cause heart disease. As an example of the first situation, we can mention dilated cardiomyopathies, which can lead to renal failure of the pre-renal type due to the state of renal hypoflow. As an example of the second situation, we can remember that renal failure is a risk factor for cardiovascular diseases, such as coronary heart disease, due to the acceleration in the process of atherosclerosis that it promotes....