When used, cocaine causes the brain to release higher than normal amounts of some chemicals. These produce a sense of euphoria, or a “high.” Cocaine intoxication is a condition in which you’re not only high from using the drug, but you also have body-wide symptoms that can make you ill and impaired.
Wiki Number: W045
Diagnosis: Cocaine Intoxication
US Patients: 15,000 deaths
Sex Ratio: 3M; 1F
Brain Area: raises dopamine and serotonin in the nucleus accumbens
Symptoms: Can be a single big dose or more over time;
Progression: heart or kidney failure, stroke, hallucinations or delusions; death from overdose
Causes: Cocaine over-use or use over time.
Medications: propanolol, buprenorphine, naltrexone; benzodiazepine, nitric oxide, alpha and beta-blockers
Therapies: Bring back blood flow to the heart and brain
4 CURRENT ARTICLES
The world-wide medical research
reports chosen for each diagnosis
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PubMed article’s summary-abstract.
- Many Drugs of Abuse May Be Acutely Transformed to Dopamine, Norepinephrine and Epinephrine In Vivoby Paul J Fitzgerald on October 13, 2021
It is well established that a wide range of drugs of abuse acutely boost the signaling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, where norepinephrine and epinephrine are major output molecules. This stimulatory effect is accompanied by such symptoms as elevated heart rate and blood pressure, more rapid breathing, increased body temperature and sweating, and pupillary dilation, as well as the intoxicating or euphoric subjective properties of the drug....
- Choosing between cocaine and sucrose under the influence: testing the effect of cocaine toleranceby Youna Vandaele on October 1, 2021
CONCLUSION: Thus, other mechanisms must be invoked to explain the influence of cocaine intoxication on choice outcomes.
- Toxicological Analysis of Intoxications with Synthetic Cathinonesby Ewelina Pieprzyca on September 30, 2021
Synthetic cathinones (SCs) are currently the second largest and the second most frequently seized group of new psychoactive substances. They are sold as replacements for controlled stimulants such as amphetamine, cocaine and MDMA. Administration of low doses of SCs can cause euphoria and increased alertness, and administration of high doses or chronic use of cathinones can cause serious adverse effects, such as hallucinations, delirium, hyperthermia, and tachycardia. In the years 2013-2019 in...
- Prehospital Ketamine Administration for Excited Delirium with Illicit Substance Co-Ingestion and Subsequent Intubation in the Emergency Departmentby Joshua J Solano on September 23, 2021
CONCLUSION: Patients treated with ketamine IM for excited delirium with concomitant cocaine intoxication had a statistically significant 5.75-fold increased rate of subsequent intubation in the ED. Amongst other substances, no other trends with intubation were noted, but further study is warranted.